摘要
目的探讨消癥汤联合米非司酮对子宫肌瘤患者血清肿瘤标志物及肿瘤相关因子水平的影响。方法选取首都医科大学附属北京同仁医院2019年12月至2022年12月收治的子宫肌瘤患者120例,按治疗方案的不同分为观察组和对照组,各60例。两组患者均予米非司酮片口服,观察组患者加服消癥汤。两组均持续治疗14周。结果观察组总有效率为98.33%,显著高于对照组的85.00%(P<0.05)。两组患者治疗后的子宫体积及子宫肌瘤体积较治疗前显著缩小(P<0.05),血清肿瘤标志物(糖类抗原125、人附睾分泌蛋白4)、雌激素、肿瘤相关因子(血管内皮生长因子、γ干扰素、肿瘤坏死因子-α、基质金属蛋白酶-9)水平均较治疗前显著降低(P<0.05);且观察组上述指标改善幅度均显著大于对照组(P<0.05)。观察组与对照组的不良反应发生率无显著差异(5.00%比10.00%,P>0.05)。结论消癥汤联合米非司酮治疗子宫肌瘤,可降低患者血清肿瘤标志物及肿瘤相关因子水平,缩小子宫肌瘤体积。
Objective To investigate the effect of Xiaozheng Decoction combined with mifepristone on the levels of serum tumor markers and tumor-related factors in patients with uterine myoma.Methods A total of 120 patients with uterine myoma admitted to the Beijing Tongren Hospital,Capital Medical University from December 2019 to December 2022 were selected and divided into the observation group and the control group based on different treatment methods,with 60 cases in each group.The patients in the two groups were given Mifepristone Tablets orally,on this basis,the patients in the observation group were given Xiaozheng Decoction.Both groups were treated continuously for 14 weeks.Results The total effective rate in the observation group was 98.33%,which was significantly higher than 85.00%in the control group(P<0.05).After treatment,the uterine and myoma volumes in the two groups significantly decreased(P<0.05);the serum tumor markers[carbohydrate antigen 125(CA125),human epididymis protein 4(HE4)],estrogen,tumor-related factors[(vascular endothelial growth factor(VEGF),interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),matrix metalloproteinase-9(MMP-9)]levels significantly decreased(P<0.05);and the above indexes in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(5.00%vs.10.00%,P>0.05).Conclusion Xiaozheng Decoction combined with mifepristone in the treatment of uterine myoma can decrease the levels of serum tumor markers and tumor-related factors in patients,and decrease the uterine myoma volume.
作者
高凌琴
刘静云
杨静
GAO Lingqin;LIU Jingyun;YANG Jing(Beijing Tongren Hospital,Capital Medical University,Beijing,China 100176;Tangshan Central Hospital,Tangshan,Hebei,China 063000)
出处
《中国药业》
CAS
2024年第4期104-107,共4页
China Pharmaceuticals
基金
河北省医学科学研究课题计划[20231828]。
关键词
消癥汤
米非司酮
子宫肌瘤
血清肿瘤标志物
肿瘤相关因子
临床疗效
Xiaozheng Decoction
mifepristone
uterine myoma
serum tumor marker
tumor-related factor
clinical efficacy
