摘要
目的探讨基于风险管理的精细化干预对结直肠癌患者围化疗期心理痛苦程度、生活质量和不良反应的影响。方法依据干预方法的不同将150例结直肠癌患者分为观察组和对照组,每组75例,对照组患者围化疗期给予常规干预,观察组患者围化疗期给予基于风险管理的精细化干预。比较两组患者的临床疗效、心理痛苦程度[美国国立综合癌症网络(NCCN)心理痛苦温度计(DT)]、生活质量[癌症患者生命质量测定量表(FACT-G)]和不良反应。结果观察组患者的客观缓解率(ORR)为73.33%,与对照组患者的61.33%无差异(P﹥0.05)。干预后,两组患者心理痛苦程度评分均低于本组干预前,观察组患者心理痛苦程度评分低于对照组(P﹤0.05)。干预后,两组患者FACT-G量表各维度评分均高于本组干预前,观察组患者FACT-G量表各维度评分均低于对照组(P﹤0.05)。观察组患者的不良反应总发生率为14.67%,明显低于对照组患者的37.33%(P﹤0.01)。结论基于风险管理的精细化干预应用于结直肠癌患者围化疗期,可改善患者的心理痛苦程度和生活质量,且安全性较高。
Objective To investigate the effect of risk management-based refined intervention on the psychological distress,quality of life,and adverse events of patients with colorectal cancer during the peri-chemotherapy period.Method A total of 150 colorectal cancer patients were divided into observation group and control group based on different intervention methods,with 75 cases in each group.Patients in the control group were given routine intervention during the peri-chemotherapy period,while patients in the observation group were given risk management-based refined intervention during the peri-chemotherapy period.The clinical efficacy,psychological pain[National Comprehensive Cancer Network(NCCN)distress thermometer(DT)],quality of life[functional assessment of cancer therapy-general(FACT-G)],and adverse events were compared between the two groups.Result The objective response rate(ORR)in the observation group was 73.33%,which was not significantly different from 61.33%in the control group(P>0.05).After the intervention,the psychological pain scores of both groups were lower than those before the intervention,and the psychological pain score of the observation group was lower than that of the control group(P<0.05).After the intervention,the scores of all dimensions of the FACT-G scale in both groups were higher than those before the intervention,while the scores of all dimensions of the FACT-G scale in the observation group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was 14.67%,significantly lower than 37.33%in the control group(P<0.01).Conclusion The risk management-based refined intervention should be applied to colorectal cancer patients during the peri-chemotherapy period,which can improve their psychological pain and quality of life,and has high safety.
作者
刘燕燕
仲秋月
王晓丽
赵芳芳
吴梦婕
牛雪瑶
LIU Yanyan;ZHONG Qiuyue;WANG Xiaoli;ZHAO Fangfang;WU Mengjie;NIU Xueyao(First Department of Gastroenterology,He’nan Cancer Hospital,Zhengzhou 450003,He’nan,China)
出处
《癌症进展》
2023年第24期2749-2752,共4页
Oncology Progress
基金
河南省科技攻关项目(212102310198)。
关键词
结直肠癌
围化疗期
基于风险管理的精细化干预
不良反应
colorectal cancer
peri-chemotherapy period
risk management-based refined intervention
adverse event
