摘要
脂联素是一种脂肪因子,在人血浆中含量最为丰富,并且是由白色脂肪组织(WAT)产生的一种分泌性蛋白,血清中脂联素的表达水平与一些代谢相关的慢性炎症息息相关,其中包括2型糖尿病和肥胖。肥胖是目前生活水平提高后人们面临的一大难题,其与慢性轻微炎症和氧化应激反应有关,而肥胖又作为乳腺癌发生发展过程中一项独立的危险因素。乳腺肿瘤的炎性脂肪微环境包括600多种富含脂肪细胞的分泌因子,这是一些具有一系列促炎和抗炎作用的生物活性多肽,这些脂肪因子与乳腺癌的发生发展有密切的关联。本次研究进一步探究脂联素与乳腺癌肥胖患者之间的关系。
Adiponectin is an adipokine that is most abundant in human plasma and is a secreted protein produced by white adipose tissue(WAT).Serum adiponectin expression levels are associated with a number of metabolically related chronic inflammation,including type 2 diabetes mellitus and obesity.Obesity is a major problem faced by people after the improvement of living standards.It is related to chronic mild inflammation and oxidative stress,and obesity is an independent risk factor in the occurrence and development of breast cancer.The inflammatory fat microenvironment of breast tumors includes more than 600 adipocyte rich secretory factors,which are bioactive polypeptides with a series of pro-inflammatory and anti-inflammatory effects,and these adipokines are closely related to the occurrence and development of breast cancer.This study further explored the relationship between adiponectin and obese patients with breast cancer.
作者
刘俊杰
朱娟英
LIU Jun-jie;ZHU Juan-ying(Zhejiang University of Chinese Medicine,Hangzhou 310053,China)
出处
《中国实用医药》
2024年第3期164-167,共4页
China Practical Medicine
关键词
脂联素
肥胖
乳腺癌
Adiponectin
Obese
Breast cancer
