摘要
目的:观察腹腔镜手术治疗结肠癌的疗效及对基质金属蛋白酶-11(MMP-11)、转录因子Sp1和基质金属蛋白酶组织抑制因子-1(TIMP-1)的影响。方法:选取我院2020-2022年收治的结肠癌患者86例,将其随机分为对照组和观察组,每组43例。对照组患者采用常规开腹手术治疗,观察组患者采用腹腔镜手术治疗,比较2组患者的手术情况、治疗效果、MMP-11、转录因子Sp1、TIMP-1的阳性率和生命质量评分(QOL)。结果:治疗后观察组患者手术时间、术后首次排气时间均短于对照组(P<0.05),术中出血量少于对照组(P<0.05);观察组患者治疗总有效率明显高于对照组(P<0.05);观察组患者的MMP-11、Sp1和TIMP-1的阳性率明显低于对照组(P<0.05);QOL评分方面,2组患者治疗前QOL评分比较差异无统计学意义(P>0.05),治疗后观察组患者身体状况、行为、自评生活质量和肠道功能评分明显高于对照组(P<0.05)。结论:实施腹腔镜手术在结肠癌治疗方面效果显著,不但缩短了手术时间,减少术中出血量,而且还可以提高患者日常身心健康和生活质量,促进患者身体康复,值得临床推广应用。
Objective To observe the clinical efficacy of laparoscopic operation on colon cancer and its effects on matrix metalloproteinase-11(MMP-11),transcription factor Sp1and tissue inhibitor of metallo-proteinase-1(TIMP-1).Methods A total of 86patients with colon cancer admitted to our hospital from 2020to 2022were selected and randomly divided into the control group and the observation group,with 43 cases in each group.Patients in the control group were treated with conventional operation,and patients in the observation group were treated with laparoscopic operation.The condition during operation,therapeu-tic effect,positive rate of MMP-11,transcription factor Sp1,TIMP-1and quality of life(QOL)score of the two groups were compared.Results After treatment,the operation time and the first postoperative ex-haust time of the observation group were shorter than those of the control group(P<0.05),and the intr-aoperative blood loss of the observation group was less than that of the control group(P<0.05).The to-tal effective rate of the observation group was significantly higher than that of the control group(P<0.05).The positive rates of MMP-11,Sp1and TIMP-1in the observation group were significantly lower than those in the control group(P<0.05).In terms of QOL score,there was no significant difference be-tween the two groups before treatment(P<0.05).After treatment,the scores of physical status,behav-ior,self-rated QOL and intestinal function in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Laparoscopic operation is effective in the treatment of colon cancer,which can not only shorten the operation time and reduce the amount of intraoperative blood loss,but also improve the daily physical and mental health and QOL of patients,and promote the physical reha-bilitation of patients,which is worthy of clinical application.
作者
赵聪聪
周博
ZHAO Cong-cong;ZHOU Bo(Operation Room,First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000)
出处
《中国肛肠病杂志》
2024年第1期4-6,共3页
Chinese Journal of Coloproctology
