摘要
目的探讨糖脂代谢指标联合抗磷脂抗体与动脉粥样硬化患者预后的相关性。方法选取2021年4月至2023年3月在河北省人民医院进行治疗128例动脉粥样硬化患者分为观察组,另外选取48例体检健康者作为对照组,对比两组糖脂代谢指标、抗磷脂抗体水平,ROC分析糖脂代谢指标、抗磷脂抗体及联合检测对动脉粥样硬化患者预后的预测价值。结果观察组TC、TG、ACL、抗β2-GP1水平高于对照组(P<0.05)。观察组动脉粥样硬化患者预后不良组TC、TG、ACL、抗β2-GP1表达水平高于预后良好组(P<0.05)。TC、TG、ACL、抗β2-GP1水平与动脉粥样硬化患者预后不良呈正相关(P<0.05)。ROC曲线显示,6项联合检测对动脉粥样硬化患者预后的预测价值高于TC、TG、ACL、抗β2-GP1单项预测价值(P<0.05)。结论TC、TG、ACL、抗β2-GP1联合检测对动脉粥样硬化患者预后的预测价值较高。
Objective To explore the correlation of glucose and lipid metabolism indicators combined with antiphospholipid antibodies with the prognosis of patients with atherosclerosis.Methods A total of 128 patients with atherosclerosis treated in our hospital from April 2021 to March 2023 were selected as study group,and 48 healthy individuals as control group.Glycolipid metabolism indexes and antiphospholipid antibody level of the two groups were compared,and the predictive value of glycolipid metabolism indexes,antiphospholipid antibodies and combined detection for the prognosis of patients with atherosclerosis were analyzed by ROC.Results TC,TG,ACL,and anti-β2-GP1 in the study group was higher than that in the control group(P<0.05).The study group was divided into two sub-groups according to the prognosis.The expression level of TC,TG,ACL,and anti-β2-GP1 in poor prognosis group was higher than that in good prognosis group(P<0.05).TC,TG,ACL,and anti-β2-GP1 was positively correlated with the poor prognosis of patients with atherosclerosis(P<0.05).ROC curve showed that the predictive value of six combined tests for the prognosis of patients with atherosclerosis was higher than that of single test of TC,TG,ACL,and anti-β2-GP1(P<0.05).Conclusion The combined detection of TC,TG,ACL,and anti-β2-GP1 has high predictive value for the prognosis of patients with atherosclerosis.
作者
崔佳
张明明
王娜
高伟
李菲
CUI Jia;ZHANG Mingming;WANG Na;GAO Wei;LI Fei(Department of Clinical Laboratory,Hebei Provincial People′s Hospital,Shijiazhuang 050051,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第3期326-329,共4页
The Journal of Practical Medicine
基金
河北省医学科学研究科技计划项目(编号:20210778)。
关键词
动脉粥样硬化
糖脂代谢指标
抗磷脂抗体
预后
atherosclerosis
indicators of glucose and lipid metabolism
antiphospholipid antibody
prognosis
