摘要
糖尿病(DM)是一种常见的代谢性疾病,其高血糖状态可诱发多种并发症,甚至威胁人类健康和生命安全。铁蛋白自噬作为目前的研究热点,已被证实与糖尿病及其并发症的发生和发展有关。铁蛋白自噬是细胞选择性自噬的一种类型,该过程由核受体共激活因子4(NCOA4)介导,使铁蛋白在自噬体中降解并释放过量的铁离子导致铁过载,引发活性氧积聚,是细胞铁死亡的重要上游机制。现就铁蛋白自噬相关机制以及它在DM及其并发症中的发病机制进行综述,进一步分析通过调控铁蛋白自噬对DM及其并发症的影响,为进一步防治DM及其并发症提供新的思路。
Diabetes mellitus(DM)is a common metabolic disease,and its hyperglycemia can induce many complications and even threaten human health and life.Ferritinophagy,currently a research focus,has been proven to be related to the occurrence and development of DM and its complications.Ferritinophagy,which is cellselective,is mediated by nuclear receptor coactivator 4(NCOA4),which degrades ferritin in autophagosomes and releases excessive iron ions so that irons are overloaded and ROS are accumulated.This process contributes to the upstream ferroptosis.This article reviews the mechanism of ferritinophagy and its pathogenesis in DM and its complications,and further analyzes the effects of regulated ferritinophagy on DM and its complications,pro⁃viding new insight into the prevention and treatment of DM and its complications.
作者
石建梅
王茜茜
韦晓洁
SHI Jianmei;WANG Xixi;WEI Xiaojie(School of Basic Medical Sciences,Guangxi University of Traditional Chinese Medicine,Nanning 530299,China;Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine,Nanning 530299,China)
出处
《实用医学杂志》
CAS
北大核心
2024年第3期417-422,427,共7页
The Journal of Practical Medicine
基金
国家自然科学基金资助项目(编号:82260881)
广西自然科学基金资助项目(编号:2020GXNSFAA297181)
广西中医药大学硕士研究生科研创新项目(编号:YCSW2022360)
广西中医药大学“岐黄工程”高层次人才团队培育项目(编号:202402)。
关键词
铁蛋白
铁蛋白自噬
核受体共激活因子4
糖尿病
ferritin
ferritinophagy
nuclear receptor coactivator 4
diabetes mellitus
