摘要
目的探究黄芩苷辅助治疗青光眼的临床疗效。方法回顾性分析72例青光眼患者的临床资料,根据治疗方法进行分组,观察组36例(36眼)予以黄芩苷+布林佐胺滴眼液治疗,对照组36例(36眼)仅予布林佐胺滴眼液治疗。2组均连续治疗4周。比较2组临床总有效率及患眼治疗前后眼压、矫正视力和眼血流动力学参数的变化。结果治疗后,观察组临床总有效率为94.44%,显著高于对照组的77.78%(P<0.05)。2组患眼眼压均较治疗前降低(P均<0.05),且观察组显著低于对照组(P<0.05);2组患眼矫正视力均较治疗前升高(P均<0.05),且观察组显著高于对照组(P<0.05)。2组患眼视野平均缺损均较治疗前降低(P均<0.05),光敏感度较治疗前增高(P<均0.05);且观察组视野平均缺损显著低于对照组(P<0.05),光敏感度显著高于对照组(P<0.05)。2组患眼视网膜中央动脉(central retinal artery,CRA)的收缩期峰值流速(peak systolic velocity,PSV)、舒张末期血流速度(end diastolic velocity,EDV)等血流动力学指标均较前升高(P均<0.05),且观察组上述指标显著高于对照组(P均<0.05);2组患眼CRA的阻力指数(resistance index,RI)较前降低(P均<0.05),且观察组显著低于对照组(P<0.05)。结论黄芩苷辅助治疗青光眼可取得更为满意的治疗效果,可改善眼血流动力学参数,有助于降低眼压,提高矫正视力。
Objective To explore the clinical efficacy of baicalin as an adjuvant therapy for glaucoma.Methods A retrospective analysis was conducted on the clinical data of 72 glaucoma patients,who were divided into two groups according to the treatment method.A total of 36 cases(36 eyes)in the observation group were treated with baicalin and brinzolamide eye drops,while 36 cases(36 eyes)in the control group were only treated with brinzolamide eye drops.Both groups were treated continuously for 4 weeks.The total clinical effective rate and changes of the intraocular pressure,corrected visual acuity,and ocular hemodynamic parameters before and after treatment in the two groups were compared.Results After treatment,the total clinical effective rate of the observation group was 94.44%,which was significantly higher than the 77.78%of the control group(P<0.05).The intraocular pressure of both groups decreased compared to those before treatment(P all<0.05),and the observation group was significantly lower than the control group(P<0.05).The corrected visual acuity of both groups increased compared to those before treatment(P all<0.05),and the observation group was significantly higher than the control group(P<0.05).The average visual field defect in both groups decreased compared to those before treatment(P all<0.05),and the light sensitivity increased(P all<0.05).And the average visual field defect in the observation group was significantly lower than that in the control group(P<0.05),and the light sensitivity was significantly higher than that in the control group(P<0.05).The hemodynamic indicators of peak systolic velocity(PSV)and end diastolic velocity(EDV)of the central retinal artery(CRA)in the two groups were significantly higher than those before treatment(P all<0.05),while the above indicators in the observation group were significantly higher than those in the control group(P all<0.05).The resistance index(RI)of CRA in the two groups decreased(P all<0.05),and the observation group was significantly lower than the control group(P<0.05).Conclusion Baicalin as an adjuvant therapy for glaucoma could achieve more satisfactory therapeutic effects,which also ameliorate eye hemodynamic parameters,reduce intraocular pressure,and improve corrected visual acuity.
作者
张丽萍
ZHANG Liping(Health Management Center,the First Affiliated Hospital of Henan University ofTraditional Chinese Medicine,Zhengzhou 450000,China)
出处
《中西医结合研究》
2024年第1期27-30,共4页
Research of Integrated Traditional Chinese and Western Medicine
基金
河南省中医药科学研究专项课题(No.20-21ZY2199)。
关键词
黄芩苷
青光眼
视力
眼压
baicalin
glaucoma
visual acuity
intraocular pressure
