摘要
目的探讨基于“阴阳消长转化”理论分期针刺对早发性卵巢功能不全(POI)患者卵巢功能的影响。方法选取2019年12月-2022年12月琼海市中医院门诊就诊的150例肾虚肝郁型POI患者作为研究对象,采用随机数表法分为对照组与观察组,各75例。对照组给予激素替代疗法治疗,观察组给予基于“阴阳消长转化”理论分期针刺治疗。连续治疗3个月经周期。比较2组治疗3个月经周期后的临床疗效,治疗前、治疗1、3个月经周期后的中医证候积分,治疗前、治疗3个月经周期后的心理状态、围绝经期症状评分、睡眠质量、生存质量及卵巢功能。结果治疗3个月经周期后,观察组总有效率(96.00%,72/75)高于对照组(70.67%,53/75)(P<0.05)。2组中医证候积分比较,治疗1个月经周期后低于治疗前,治疗3个月经周期后低于治疗前、治疗1个月经周期后,且治疗1、3个月经周期后,观察组低于对照组(P<0.05)。与治疗前比较,治疗3个月经周期后,2组抑郁自评量表(SDS)、焦虑自评量表(SAS)、改良Kupperman指数(KI)、匹兹堡睡眠质量指数量表(PSQI)评分及血清促卵泡激素(FSH)、促黄体生成素(LH)水平均降低,且观察组低于对照组;生存质量测定量表-100(QOL-100)评分、血清雌二醇(E2)、抗苗勒管激素(AMH)水平、卵巢总体积(TOV)及双侧卵巢中的基础窦卵泡计数(AFC)均升高,且观察组高于对照组(P<0.05)。结论基于“阴阳消长转化”理论分期针刺法可有效缓解肾虚肝郁型POI患者相关临床症状,恢复患者卵巢功能,有助于缓解患者负面心理状态,并改善睡眠质量,提高患者生存质量,临床疗效较好。
Objective To explore the effect of staging acupuncture on ovarian function in patients with premature ovarian insuficiency(POI)based on the theory of"transformation of waxing and waning of yin-yang".Methods 150 patients with POI of kidney deficiency and stagnation of liver qi type admitted to the outpatient department of Qionghai Hospital of Traditional Chinese Medicine from September 2019 to September 2022 were selected as the research subjects and divided into the control group(75 cases)and the observation group(75 cases)according to random number table method.The control group was treated with hormone replacement therapy,and the observation group was treated with staging acupuncture based on the theory of"transformation of waxing and waning of yin-yang".All patients were treated continuously for 3 menstrual cycles.The clinical efficacy after 3 menstrual cycles of treatment,the score of traditional Chinese medicine syndrome before treatment and after 1 and 3 menstrual cycles of treatment,and psychological state,the score of perimenopausal symptom,quality of sleep,quality of life and ovarian function before treatment and after 3 menstrual cycles of treatment of two groups were compared.Results After 3 menstrual cycles of treatment,the total effective rate in the observation group(96.00%,72/75)was higher than that in the control group(70.67%,53/75)(P<0.05).After 1 menstrual cycle of treatment,the scores of traditional Chinese medicine syndrome of two groups were lower than those before treatment;After 3 menstrual cycles of treatment,the scores of traditional Chinese medicine syndrome of two groups were lower than those before treatment and after 1 menstrual cycle of treatment;And after 1 and 3 menstrual cycles of treatment,the observation group was lower than the control group(P<0.05).Compared with before treatment,after 3 menstrual cycles of treatment,the scores of Self-rating Depression Scale(SDS),Self-rating Anxiety Scale(SAS),Modified Kupperman Index(KI)and Pittsburgh Sleep Quality Index(PSQI),and the levels of serum follicle-stimulating hormone(FSH)and luteinizing hormone(LH)in two groups decreased,and the observation group was lower than the control group;The score of quality of life scale-100(QOL-100),the levels of serum estradiol(E2)and anti-Mullerian hormone(AMH),total ovarian volume(TOV),and basic antral follicle count(AFC)in both ovaries increased,and the observation group was higher than the control group(P<0.05).Conclusion The staging acupuncture based on the theory of"transformation of waxing and waning of yin-yang"can effectively relieve the clinical symptoms of patients with POI of kidney deficiency and stagnation of liver qi type,recover the ovarian function of patients,help alleviate the negative psychological state of patients,improve the quality of sleep,and enhance the quality of life of patients.This therapy has good clinical efficacy.
作者
岳昌华
牛向馨
王小蔓
刘穗
罗小妹
郑全成
YUE Changhua;NIU Xiangxin;WANG Xiaoman;LIU Sui;LUO Xiaomei;ZHENG Quancheng(Department of Gynecology,Qionghai Hospital of Traditional Chinese Medicine,Qionghai 571400,China;Department of Reproductive Medicine,Qionghai Hospital of Traditional Chinese Medicine,Qionghai 571400,China;Department of Acupuncture and Moxibustion,Sanya Hospital of Traditional Chinese Medicine,Sanya 572022,China)
出处
《长春中医药大学学报》
2024年第2期184-188,共5页
Journal of Changchun University of Chinese Medicine
基金
海南省卫生健康行业科研项目(20A200199)。
关键词
早发性卵巢功能不全
肾虚肝郁型
针刺
卵巢功能
premature ovarian insufficiency
kidney deficiency and stagnation of liver qi type
acupuncture
ovarian function
