摘要
目的 探讨分化型甲状腺癌(DTC)组织中甲状腺转录因子-1(TTF-1)、半乳糖凝集素-3(Galectin-3)表达水平与患者临床表现、预后的关系。方法 选取2017年1月1日至2020年5月30日该院收治的76例DTC患者作为研究对象,将手术过程中取得的癌组织标本纳入DTC组(n=76),将对应的癌旁组织标本纳入癌旁组(n=76)。免疫组化法检测TTF-1、Galectin-3在DTC组及癌旁组的表达情况,并分析TTF-1、Galectin-3表达水平与DTC患者临床病理特征的关系。采用多因素Cox回归分析探讨影响DTC患者预后的相关因素。结果 DTC组TTF-1、Galectin-3阳性表达率高于癌旁组,差异有统计学意义(P<0.05)。TNM分期为Ⅲ~Ⅳ期、低分化、组织分型为甲状腺乳头状癌、有淋巴结转移的DTC患者TTF-1阳性表达率、Galectin-3阳性表达率高于TNM分期为Ⅰ~Ⅱ期、中/高分化、组织分型为甲状腺滤泡癌、无淋巴结转移的DTC患者,差异有统计学意义(P<0.05)。TTF-1阴性、Galectin-3阴性DTC患者的3年总生存率高于TTF-1阳性、Galectin-3阳性DTC患者,差异有统计学意义(P<0.05)。多因素Cox回归分析结果显示,有淋巴结转移、TTF-1阳性、Galectin-3阳性是DTC患者预后的影响因素(P<0.05)。结论 TTF-1、Galectin-3与DTC患者TNM分期、分化程度、组织分型、淋巴结转移及3年生存率有关,对DTC患者病情判断及预后评估有重要参考价值。
Objective To investigate the relationship between the expression levels of thyroid transcription factor-1(TTF-1)and Galectin-3 in differentiated thyroid carcinoma(DTC)tissues and clinical manifestations and prognosis of patients.Methods A total of 76 DTC patients admitted to the hospital from January 1,2017 to May 30,2020 were selected as the study objects.Cancer tissue specimens obtained during surgery were included in the DTC group(n=76),and corresponding paracancer tissue specimens were included in the paracancer group(n=76).The expressions of TTF-1 and Galectin-3 in DTC group and paracancer group were detected by immunohistochemistry,and the relationship between the expression levels of TTF-1 and Galectin-3 and the clinicopathological characteristics of DTC patients was analyzed.Multivariate Cox regression analysis was used to investigate the prognostic factors of DTC patients.Results The positive expression rates of TTF-1 and Galectin-3 in DTC group were higher than those in paracancer group,and the difference was statistically significant(P<0.05).The TTF-1 positive expression rate and Galectin-3 positive expression rate in DTC patients with TNM stageⅢtoⅣ,low differentiation,tissue type of papillary thyroid carcinoma and lymph node metastasis were higher than those in DTC patients with TNM stageⅠtoⅡ,medium/high differentiation,tissue type of thyroid follicular carcinoma and no lymph node metastasis.The difference was statistically significant(P<0.05).The 3-year overall survival rate of TTF-1 negative and Galectin-3 negative DTC patients was higher than that of TTF-1 positive and Galectin-3 positive DTC patients,and the difference was statistically significant(P<0.05).Multivariate Cox regression analysis showed that lymph node metastasis,positive TTF-1 and positive Galectin-3 were prognostic factors in DTC patients(P<0.05).Conclusion TTF-1 and Galectin-3 are related to TNM stage,differentiation degree,tissue type,lymph node metastasis and 3-year survival rate of DTC patients,and have important reference value for the diagnosis and prognosis evaluation of DTC patients.
作者
史良平
王传彬
程义壮
赵玮
夏梦华
毕丽琴
SHI Liangping;WANG Chuanbin;CHENG Yizhuang;ZHAO Wei;XIA Menghua;BI Liqin(Department of Nuclear Medicine,Anhui Cancer Hospital,Hefei,Anhui 230000,China;Department of Imaging,Anhui Cancer Hospital,Hefei,Anhui 230000,China)
出处
《国际检验医学杂志》
CAS
2024年第4期457-461,共5页
International Journal of Laboratory Medicine
基金
安徽省卫生健康委员会项目(AHWJ2021b153)。
