摘要
目的分析高危人工流产术后应用雌二醇片/雌二醇地屈孕酮片(商品名:芬吗通)预防宫腔粘连(IUA)的效果。方法66例接受高危人工流产手术患者,按照年龄、孕周、孕产次、子宫畸形、抽烟等均衡分为对照组和观察组,每组33例。对照组术后采用传统治疗,观察组术后在对照组基础上使用芬吗通。比较两组患者治疗前后血液流变学指标、白细胞介素水平及IUA发生情况。结果治疗后,观察组全血粘度、血浆粘度分别为(3.58±1.21)、(1.34±0.14)mPa·s,低于对照组的(5.67±1.39)、(1.49±0.23)mPa·s(P<0.05)。治疗前,观察组白细胞介素-10(IL-10)、白细胞介素-18(IL-18)水平分别为(1003.06±196.66)、(176.32±29.21)ng/L,对照组分别为(1008.37±193.18)、(175.78±29.45)ng/L;治疗后,观察组IL-10、IL-18水平分别为(3102.54±583.27)、(113.15±23.62)ng/L,对照组分别为(2647.63±521.53)、(130.09±18.30)ng/L。治疗后,两组IL-10水平均明显升高,IL-18水平均明显降低,且观察组IL-10水平较对照组高,IL-18水平较对照组低(t=3.340、3.257,P<0.05)。观察组术后IUA发生率为3.03%,较对照组的24.24%低(P<0.05)。结论高危人工流产术后应用芬吗通预防IUA疗效显著且安全,可借鉴。
Objective To analyze the effect of using trade name:complex packing estradiol tablets/estradioland dydrogesterone tablets(trade name:Fenmoston)to prevent intrauterine adhesions(IUA)after high-risk induced abortion.Methods 66 patients who underwent high-risk induced abortion were selected.According to age,gestational age,gravidity and parity history,uterine malformation,smoking and so on,they were divided into a control group and an observation group,with 33 cases in each group.The control group was given traditional treatment,and the observation group was treated with Fenmoston after operation.The hemorheology indexes and interleukin levels before and after treatment,and IUA occurrence were compared between the two groups.Results After treatment,the whole blood viscosity and plasma viscosity of the observation group were(3.58±1.21)and(1.34±0.14)mPa·s,which were lower than(5.67±1.39)and(1.49±0.23)mPa·s of the control group(P<0.05).Before treatment,the levels of interleukin-10(IL-10)and interleukin-18(IL-18)in the observation group were(1003.06±196.66)and(176.32±29.21)ng/L,and those in the control group were(1008.37±193.18)and(175.78±29.45)ng/L.After treatment,the levels of IL-10 and IL-18 were(3102.54±583.27)and(113.15±23.62)ng/L in the observation group,and(2647.63±521.53)and(130.09±18.30)ng/L in the control group.After treatment,the IL-10 level was significantly increased in both groups,and the IL-18 level was significantly decreased in both groups;and the IL-10 level in the observation group was higher than that in the control group,and the IL-18 level was lower than that in the control group(t=3.340,3.257;P<0.05).Conclusion Fenmoston is effective and safe in preventing IUA after high-risk induced abortion,which can be used for reference.
作者
洪丽仁
HONG Li-ren(Xiamen Changgeng Hospital,Xiamen 361028,China)
出处
《中国现代药物应用》
2024年第3期97-100,共4页
Chinese Journal of Modern Drug Application
关键词
宫腔粘连
血液流变学
疗效
安全性
血浆粘度
雌二醇片/雌二醇地屈孕酮片
Intrauterine adhesions
Hemorheology
Efficacy
Safety
Plasma viscosity
Complex packing estradiol tablets/estradioland dydrogesterone tablets
