摘要
目的探究沙库巴曲缬沙坦在慢性心力衰竭(chronic heart failure,CHF)患者中的应用效果。方法选取2021年9月至2022年9月新余袁河医院收治的66例CHF患者,根据随机数字表法将其分为对照组和研究组,每组各33例。对照组患者给予贝那普利+螺内酯+美托洛尔治疗,研究组患者给予沙库巴曲缬沙坦+螺内酯+美托洛尔治疗,比较两组患者的临床疗效、心室重构、心功能、血清因子水平及不良反应。结果研究组患者的总有效率显著高于对照组(χ2=5.974,P=0.015);治疗后,研究组患者的左心室质量指数、室壁应力、左室后壁厚度、左室射血分数、N末端脑钠肽前体(N-terminal pro-brainnatriureticpeptide,NT-proBNP)、血管紧张素Ⅱ、醛固酮均显著低于对照组,左心室重构指数、每搏输出量、左室舒张末期容积显著高于对照组(P<0.05)。两组患者的不良反应比较差异无统计学意义(P>0.05)。结论CHF患者应用沙库巴曲缬沙坦治疗疗效显著,可有效改善心功能各指标,逆转心室重构,降低血清NT-proBNP水平,且不良反应较少。
Objective To explore the application effect of sacubitril valsartan in patients with chronic heart failure(CHF).Methods A total of 66 CHF patients admitted to Xinyu Yuanhe Hospital from September 2021 to September 2022 were selected and divided into control group and study group according to random number table method,with 33 cases in each group.The control group was treated with benazepril+spironolactone+metoprolol,and the study group was treated with sacubitril valsartan+spironolactone+metoprolol.The clinical efficacy,ventricular remodeling,cardiac function,serum factor levels and adverse reactions were compared between two groups.Results The total effective rate in study group was significantly higher than that in control group(χ2=5.974,P=0.015).After treatment,left ventricular mass index,myocardial wall stress,left ventricular posterior wall thickness,left ventricular ejection fraction,N-terminal pro-brain natriuretic peptide(NT-proBNP),angiotensinⅡand aldosterone in study group were significantly lower than those in control group,and left ventricular remodelling index,stroke volume and left ventricular end-diastolic volume were significantly higher than those in control group(P<0.05).There was no significant difference in adverse reactions between two groups(P>0.05).Conclusion The treatment effect of sacubitril valsartan in CHF patients is significant,which can effectively improve cardiac function indicators,reverse ventricular remodeling,reduce serum NT-proBNP level,and have fewer adverse reactions.
作者
钟韶春
廖永生
张清录
ZHONG Shaochun;LIAO Yongsheng;ZHANG Qinglu(Department of Cardiovascular,Xinyu Yuanhe Hospital,Xinyu 338000,Jiangxi,China)
出处
《中国现代医生》
2024年第4期77-80,共4页
China Modern Doctor
关键词
慢性心力衰竭
沙库巴曲缬沙坦
N末端脑钠肽前体
心功能
Chronic heart failure
Sacubitril valsartan
N-terminal pro-brain natriuretic peptide
Cardiac function
