摘要
目的:观察门冬胰岛素结合个体化饮食及运动指导控制妊娠期糖尿病(GDM)孕妇血糖效果。方法:纳入2020年1月-2023年3月本院收治的GDM孕妇101例,随机数字表法分为观察组(50例)与对照组(51例),对照组采取常规胰岛素治疗,观察组采取门冬胰岛素结合个体化饮食及运动指导控制血糖,观察治疗前及治疗3个月后孕妇空腹血糖(FBG)及餐后2h血糖(2hPBC)、糖化血红蛋白(HbAlc)等血糖指标,空腹胰岛素(FINS)及稳态模型胰岛β细胞功能指数(HOMA-β)、稳态模型胰岛素抵抗指数(HOMA-IR)等胰岛功能指标,超氧化物歧化酶(SOD)与活性氧(ROS)水平、谷胱甘肽过氧化物酶(GSH-Px)等氧化应激指标变化,治疗依从性及治疗满意率,并观察不良结局发生率。结果:治疗3个月后观察组血糖FBG(4.75±0.46mmol/L)、2hPBC(5.84±0.60mmol/L)、HbAlc(6.05±0.41)%均低于对照组(5.61±0.70mmol/L、5.84±0.60mmol/L、6.47%±0.44%),胰岛功能指标、氧化应激指标均优于对照组,观察组依从率(98.0%)及治疗满意率(96.0%)均高于对照组(84.3%、82.4%),产妇不良结局(2.0%)及新生儿不良结局(4.0%)均低于对照组(13.7%、15.7%)(均P<0.05)。结论:门冬胰岛素结合个体化饮食及运动指导可较好帮助患者控制血糖水平,改善胰岛功能,患者依从性更好、满意率高,降低了不良结局发生。
Objective:To observe the effect of the insulin aspartate used combined with the individualized diet and exer-cise guidance for controlling the blood glucose level of pregnant women with gestational diabetes mellitus(GDM).Methods:101 pregnant women with GDM were included and were divided into observation group(50 cases)and con-trol group(51 cases)by random number table method from January 2020 to March 2023.The women in the control group were treated with conventional insulin,and the women in the observation group were treated with insulin aspar-tate combined with individualized diet and exercise guidance.The changes of the levels of the blood glucose indexes,such as fasting blood glucose(FBG),2h postprandial blood glucose(2hPBC),glycated hemoglobin(HbAlc)and oth-er,the values of islet function indexes,such as fasting insulin(FINS),homeostasis model isletβcell function index(HOMA-β),homeostasis model insulin resistance index(HOMA-IR)and other,and the levels of oxidative stress in dexes,such as oxide dismutase(SOD)and reactive oxygen species(ROS),glutathione peroxidase(GSH Px)and oth-er,of the women before treatment and after 3 months of treatment,and the treatment compliance,the treatment sat-isfaction rate and the incidence of adverse outcomes of the women in the two groups were observed.Results:After 3 months of treatment,the levels of the blood glucose FBG(4.75±0.46 mmol/L),the 2hPBC(5.84±0.60 mmol/L)and the HbAlc(6.05±0.41%)of the women in the observation group were significantly lower than those(5.61±0.70 mmol/L,5.84±0.60 mmol/L and 6.47%±0.44%)of the women in the control group.The islet function index and oxidative stress index of the women in the the observation group were significantly better than those of the women in the control group.The compliance rate(98.0%)and the treatment satisfaction rate(96.0%)of the women in the ob-servation group were significantly higher than those(84.3%and 82.4%)of the women in the control group.The rates of maternal adverse outcomes(2.0%)and neonatal adverse outcomes(4.0%)in the control group were significantly lower than those(13.7%and 15.7%)in the control group(all P<0.05).Conclusion:Insulin aspartate combined with individualized diet and exercise guidance for treating the pregnant women with GDM can better help them to control their blood sugar level and improve their islet function,increase their treatment compliance and their treatment satis-faction rate,and reduce their adverse outcomes.
作者
张文星
段丽娜
ZHANG Wenxing;DUAN Lina(Rugao People's Hospital,Nantong,Jiangsu Province,226500)
出处
《中国计划生育学杂志》
2024年第2期352-355,共4页
Chinese Journal of Family Planning
基金
南通市卫生健康委员会项目(QB2020016)。
关键词
妊娠期糖尿病
门冬胰岛素
个体化饮食
运动指导
血糖指标
不良结局
依从性
Gestational diabetes mellitus
Insulin aspartate
Individualized diet
Sports instruction
Blood glucose index
Adverse outcome
Compliance
