摘要
目的:探讨胎盘早剥患者血清抗氧化物水平变化及其与病情严重性、产后出血的关系。方法:选取2019年1月-2022年3月本院妇产科收治的胎盘早剥患者104例作为观察组,产前体检健康孕妇120例为对照组。入院后均检测血清总超氧化物歧化酶(TSOD)、尿酸(UA)、白蛋白(ALB)浓度并比较。采用Pearson相关及Spearman相关法分析血清抗氧化物水平与胎盘早剥病情、产后出血量关系,采用受试者工作特征曲线(ROC)分析血清抗氧化物对产后出血的预测效能。结果:观察组血清TSOD(78.66±6.69U/ml)、UA(358.62±35.62μmol/L)水平均高于对照组(65.47±5.10U/ml、265.69±25.64μmol/L),ALB(34.20±3.36g/L)水平低于对照组(56.65±5.62g/L)。Ⅱ度胎盘早剥孕妇血清TSOD、UA水平均高于0~Ⅰ度胎盘早剥孕妇,ALB水平均低于0~Ⅰ度胎盘早剥孕妇;产后出血量>300ml孕妇血清TSOD、UA水平均高于产后出血量≤300ml孕妇,ALB水平低于产后出血量≤300ml孕妇(均P<0.05)。胎盘早剥孕妇的病情严重程度与血清TSOD、UA水平均呈正相关,与血清ALB水平呈负相关;胎盘早剥孕妇产后出血量与血清TSOD、UA水平均呈正相关,与血清ALB水平呈负相关(均P<0.05)。ROC曲线结果显示,诊断患者产后大出血的ALB曲线下面积为0.710,截断值32.24g/L,敏感度72.2%、特异度80.63%;UA曲线下面积为0.721,截断值360.30μmol/L,敏感度75.6%、特异度85.6%;TSOD曲线下面积为0.730,截断值为80.66U/ml,敏感度76.7%、特异度89.0%。结论:胎盘早剥患者血清TSOD、UA水平升高,ALB水平降低与胎盘早剥病情严重程度及产后出血量有一定相关。
Objective:To explore the change of the serum antioxidant level of pregnant women with placental abrup-tion,and to study its correlation with the severity of placental abruption and the postpartum hemorrhage of the women.Methods:104 pregnant women with placental abruption from January 2019 to March 2022 were selected in study group.120 healthy pregnant women who came to hospital for prenatal examination were selected in control group dur-ing the same period.The levels of serum total superoxide dismutase(TSOD),uric acid(UA),and albumin(ALB)of the women in the two groups were detected and were compared between the two groups.Pearson correlation and Spearman correlation were used to analyze the correlation between the serum antioxidant level of the women with pla-cental abruption and their severity of disease and the amount of postpartum hemorrhage.Receiver operator characteris-tic(ROC)curve was used to analyze the predictive efficacy of the serum antioxidant level of the women for their post-partum hemorrhage.Results:The levels of serum TSOD(78.66±6.69 U/ml)and UA(358.62±35.62μmol/L)of the women in the study group were significantly higher than those(65.47±5.10 U/ml and 265.69±25.64μmol/L)of the women in the control group.The level of ALB(34.20±3.36 g/L)of the women in the study group was significantly lower than that(56.65±5.62 g/L)of the women in the control group.The levels of serum TSOD and UA of the women with degree Ⅰ placental abruption were significantly higher than those of the women with degree 0-Ⅰ placental abruption,but the level of ALB of the women with degree Ⅰ placental abruption was significantly lower.The serum TSOD and UA levels of the women with postpartum blood loss>300 ml were significantly higher than those of the women with postpartum blood loss≤300 ml,but the ALB level of the women with postpartum blood loss>300 ml was significantly lower(all P<0.05).The severity of placental abruption of the women was positively correlated with their serum TSOD and UA levels,and was negatively correlated with their serum ALB level.The amount of postpar-tum hemorrhage of the women with placental abruption was positively correlated with their serum TSOD and UA levels,and was negatively correlated with their serum ALB level(all P<0.005).ROC curve showed that the area under the curve,the cutoff value,the sensitivity,and the specificity of the ALB level of the women for diagnosing their postpartum hemorrhage were 0.710,32.24g/L,72.2%,and 80.63%,respectively.The area under the curve,the cutoff value,the sensitivity,and the specificity of the UA level of the women for diagnosing their postpartum hemorrhage were 0.721,360.30μmol/L,75.6%,and 85.6%,respectively.The area under the curve,the cut-off value,the sensi-tivity,and the specificity of the TSOD level of the women for diagnosing their postpartum hemorrhage were 0.730,80.66U/ml,76.7%,and 89.0%,respectively.Conclusion:The serum TSOD and UA levels of the pregnant women with placental abruption increase,and the ALB level of the women decreases,which are related to the severity of the placental abruption and the amount of postpartum hemorrhage of the women,
作者
高珊珊
张珂
张玉苓
许艇
张庆
GAO Shanshan;ZHANG Ke;ZHANG Yuling;XU Ting;ZHANG Qing(The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,450000)
出处
《中国计划生育学杂志》
2024年第2期441-445,共5页
Chinese Journal of Family Planning
基金
2017年度河南省医学科技攻关计划项目(201702091)。
关键词
胎盘早剥
抗氧化物
病情程度
产后出血
Placental abruption
Antioxidants
Severity of disease
Postpartum hemorrhage
