摘要
目的 探讨脑小血管病患者血清硫氧还蛋白2(Trx2)、磷酸化tau蛋白(P-tau)与核磁总负荷评分和认知功能的相关性。方法 选取2019年7月—2020年7月沧州市中心医院脑小血管病患者94例,根据是否存在认知功能障碍分为认知障碍组(38例)和无认知障碍组(56例);根据核磁总负荷评分分为轻度负荷组(67例)和中重度负荷组(27例)。收集所有患者的一般资料和实验室检测结果,并检测血清Trx2、P-tau水平。采用多因素Logistic回归分析评估脑小血管病患者核磁总负荷和认知功能的影响因素。采用Pearson相关分析评估各项指标与核磁总负荷和认知功能的相关性。结果 认知障碍组和无认知障碍组性别、年龄、饮酒史、吸烟史和高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、核磁总负荷评分、Trx2、P-tau水平差异均有统计学意义(P<0.05),其他指标差异均无统计学意义(P>0.05)。轻度负荷组与中重度负荷组之间性别、年龄、高血压史和HDL-C、UA、Trx2、P-tau水平差异均有统计学意义(P<0.05),其他指标差异均无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,血清Trx2[比值比(OR)值=2.751,95%可信区间(CI)为1.123~6.738]、血清P-tau(OR=2.651,95%CI为1.180~5.956)是脑小血管病患者认知功能障碍的独立危险因素(P<0.05)。Pearson相关分析结果显示,脑小血管病患者血清Trx2、P-tau与核磁总负荷评分和CMMSE评分均呈正相关(P<0.05)。结论 血清Trx2、P-tau与脑小血管病患者核磁总负荷和认知功能密切相关,检测血清Trx2、P-tau水平有助于评估脑小血管病的严重程度和患者认知功能。
Objective To investigate the correlation between serum thioredoxin 2(Trx2),phosphorylated tau(P-tau)and total magnetic resonance imaging(MRI)load score and cognitive function in patients with cerebral small vessel disease.Methods Totally,94 patients with cerebral small vessel disease in Cangzhou Central Hospital from July 2019 to July 2020 were enrolled.According to whether they had cognitive function impairment,the patients were classified into cognitive impairment group(38 cases)and non-cognitive impairment group(56 cases).According to the total MRI load score,the patients were classified into mild load group(67 cases)and moderate to severe load group(27 cases).The general data and clinical laboratory determination results were collected.Serum Trx2 and P-tau were determined,and the factors for total MRI load and cognitive function in patients with cerebral small vessel disease was analyzed by multivariant Logistic regression analysis.Pearson correlation analysis was used to evaluate the correlation between each indicator and total MRI load and cognitive function.Results There was statistical significance in sex,age,drinking history,smoking history,high-density lipoprotein cholesterol(HDL-C),uric acid(UA),total MRI load score,Trx2 and P-tau levels between cognitive impairment group and non-cognitive impairment group(P<0.05),and there was no statistical significance in the other indicators(P>0.05).There was statistical significance in sex,age,hypertension history,HDL-C,UA,Trx2 and P-tau levels between mild load group and moderate to severe load group(P<0.05),and there was no statistical significance in the other indicators(P>0.05).Serum Trx2[odds ratio(OR)=2.751,95%confidence interval(CI)1.123-6.738]and serum P-tau(OR=2.651,95%CI 1.180-5.956)were independent risk factors for cognitive function impairment in patients with cerebral small vessel disease(P<0.05).Serum Trx2 and P-tau were positively correlated with total MRI load score and CMMSE score in patients with cerebral small vessel disease(P<0.05).Conclusions Serum Trx2 and P-tau are related to total MRI load and cognitive function in patients with cerebral small vessel disease,which can be used to evaluate the severity and cognitive function of cerebral small vessel disease.
作者
段朋仓
董瑞芳
刘小满
曹阳
王若曦
DUAN Pengcang;DONG Ruifang;LIU Xiaoman;CAO Yang;WANG Ruoxi(Department of Neurology,Cangzhou Central Hospital,Cangzhou 061000,Hebei,China)
出处
《检验医学》
CAS
2024年第1期1-6,共6页
Laboratory Medicine
基金
2021年度河北省医学科学研究课题计划(20211564)。
关键词
硫氧还蛋白2
磷酸化TAU蛋白
核磁总负荷评分
认知功能
脑小血管病
Thioredoxin 2
Phosphorylated tau
Total magnetic resonance imaging load score
Cognitive function
Cerebral small vessel disease
