摘要
目的探讨非结核分枝杆菌病患者临床特征及临床分离株菌种分布和耐药情况。方法回顾性选取2020年5月-2023年2月无锡市第五人民医院收治的104例非结核分枝杆菌病患者为研究对象,分析患者基本情况、临床特征及临床分离株菌种分布和耐药情况。结果非结核分枝杆菌病患者咳嗽咳痰、发热占比较高,分别为77.88%、27.88%;伴有肺气肿、支气管扩张占比较高,分别为31.73%、23.08%;有斑片结条索、支气管扩张改变、空洞占比较高,分别为100.00%、81.73%、51.92%;104株非结核分枝杆菌临床分离菌株中胞内分枝杆菌、龟脓肿分枝杆菌、鸟分枝杆菌及堪萨斯分枝杆菌的占比较高,分别为44.23%、25.00%、12.50%及10.58%;主要非结核分枝杆菌对异烟肼、链霉素、阿米卡星和对氨基水杨酸的耐药率均为100.00%。结论临床可通过病原菌培养、临床症状、合并症及影像学特征等对非结核分枝杆菌病及时诊断,且非结核分枝杆菌中胞内分枝杆菌、龟脓肿分枝杆菌、鸟分枝杆菌及堪萨斯分枝杆菌占比较高,临床可根据药敏结果及时给予针对性的抗菌治疗。
OBJECTIVE To explore the clinical characteristics of the patients with non-tuberculous mycobacteriosis and observe the distribution and drug resistance of clinical isolates.METHODS A total of 104 patients with non-tu-berculous mycobacteriosis who were treated in Wuxi Fifth People's Hospital from May 2020 to Feb 2023 were re-cruited as the research subjects.The baseline data of the patients,clinical characteristics,distribution and drug resistance of the clinical isolates were observed.RESULTS Among the patients with non-tuberculous mycobacteri-osis,77.88%had cough and expectoration,and 27.88%had fever.31.73%were complicated with pulmonary emphysema,and 23.08%were complicated with bronchiectasis.100.00%had patches and nodules,81.73%had changes in bronchiectasia,and 51.92%had cavities.Totally 104 strains of non-tuberculous Mycobacteria were i-solated,44.23%of which were Mycobacterium intracellulare,25.00%were Mycobacteria chelonae subsp.ab-scessus,12.50%were Mycobacterium avium,and 10.58%were Mycobacterium kansasii.The drug resistance rates of the major species of non-tuberculous Mycobacteria to isoniazid,streptomycin,amikacin and aminosalicylic acid were 100.00%.CONCLUSION The non-tuberculous mycobacteriosis can be diagnosed in a timely manner by etiological culture,clinical symptoms,complications and imaging findings.M.intracellulare,Mycobacteria che-lonae subsp.abscessus,M.avium and M.kansasii are the predominant species of non-tuberculous Mycobacteria.It is necessary to carry out the targeted antibacterial treatment based on the result of drug susceptibility testing.
作者
储美萍
钱静娟
程亮
毛昕妍
郭丹丹
CHU Mei-ping;QIAN Jing-juan;CHENG Liang;MAO Xin-yan;GUO Dan-dan(Wuxi Fifth People's Hospital,Wuri,Jiangsu 214007,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2024年第1期41-44,共4页
Chinese Journal of Nosocomiology
基金
江苏省卫生健康委科研项目(Z2021063)。
关键词
非结核分枝杆菌
分布
非结核分枝杆菌病
临床特征
耐药性
Non-tuberculous Mycobacteria
Distribution
Non-tuberculous mycobacteriosis
Clinical characteristic
Drug resistance
