摘要
目的 探究全自动凝血仪在子痫前期患者凝血功能检测中的应用。方法 选取本院2019年3月-2022年3月期间的120例子痫前期患者设为研究组。轻度患者70例,重度患者50例,设为轻度组和重度组。同期选取正常妊娠孕妇120例设为对照组。采用CS-5100全自动凝血分析仪对活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fib)、凝血酶时间(TT)、D-二聚体(D-D)、纤维蛋白原降解产物(FDP)、抗凝血酶-Ⅲ(AT-Ⅲ)水平进行检测;计算不同浓度凝血七项不精密度CV值;测定APTT、PTTT日间不精密度;评判Fib、D-D、FDP、AT-Ⅲ的携带污染率,观察检测结果。结果 与对照组和轻度组相比,研究组和重度组的APTT、PT、TT、AT-Ⅲ水平降低,Fib、D-D、FDP水平升高(P <0.05);APTT、PT、Fib不同浓度(正常、中度、高度)水平的批内不精密度分别为0.475%~2.664%、0.632%~1.066%、1.995%~3.615%;单水平项目TT、D-D、FDP、AT-Ⅲ的CV批内分别为0.712%、4.241%、6.301%、5.441%;APTT、PT、TT日间不精密度较好,但Fib CV略大;Fib、D-D、FDP指标水平的判定标准均≤10%。结论 对子痫前期患者通过全自动凝血仪进行凝血七项检测,能够显著评估患者凝血功能状态,对于评估患者疾病严重程度具有关键作用,能够为临床治疗提供坚实依据,有利于后续治疗方案的制定。
Objective To explore the application of automatic coagulation instrument in the detection of coagulation function in patients with preeclampsia.Methods 120 patients with preeclampsia admitted to Beijing Chaoyang Hospital of Capital Medical University from March 2019 to March 2022 were selected as the study group.70 mild patients and 50 severe patients were as the mild group and the severe group respectively.During the same period,120 normal pregnant women were selected as the control group.The activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),and D-dimer(D-D),fibrinogen(Fib),fibrinogen degradation products(FDP)and antithrombin-III(AT-II)levels were detected by a CS-5100 automatic coagulation instrument.Seven imprecision CV values at different concentrations of coagulation were calculated.The daytime imprecision density of APTT and PTTT was measured.The carryover of Fib,D-D,FDP and AT-III was evaluated,and the test results were observed.Results Compared with the control group and the mild group,in the study group and the severe group,the levels of APTT,PT,TT and AT III decreased,and the levels of Fib,D-D,and FDP increased(P<0.05);The within-run imprecision of APTT,PT,and Fib at different concentratons(normal,moderate,high)was 0.475%-2.664%,0.632%-1.066%,and 1.995%-3.615%,respectively;The within-run CV values of single-level items TT,D-D,FDP,and AT-II were 0.712%,4.241%,6.301%,and 5.441%,respectively;With-in-day imprecision of APTT,PT,and TT was better,but the Fib CV was slightly larger;The criteria for determining the levels of Fib,D-D,and FDP were all≤10%.Conclusion For patients with preeclampsia,seven coagulation tests can be performed by using the automatic coagulation instrument,which can significantly evaluate the coagulation function status of the patients,and play a key role in assessing the severity of the disease.It can provide favorable basis for clinical treatment and facilitate the formulation of subsequent treatment plans.
作者
王涛
刘崇东
高志琪
WANG Tao;LIU Chongdong;GAO Zhiqi(Clinical Laboratory,Bejing Chaoyang Hospital,Capital Medical University,Bejing 100020,China;Department of Obstetrics and Gynecology,Beijing Chaoyang Hospital,Capital Medical University,Bejing 100020,China)
出处
《长春中医药大学学报》
2024年第1期95-98,共4页
Journal of Changchun University of Chinese Medicine
基金
北京市自然科学基金资助项目(Z191100006619032)。
关键词
子痫前期
凝血七项
全自动凝血仪
不精密度
携带污染率
preeclampsia
seven items of coagulation
automatic coagulation instrument
imprecision
carryover
