摘要
The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic chemistry.Herein,we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diarylethylene with chelation group free to enable the modular synthesis of smart material candidates,1,1,2,2-tetraarylethanes(TAEs),which represent the first protocol by assembling four different aryl groups into ethane motif.Preliminary mechanistic experiments suggest that the crucial Pd–H species generated in situ do not disengage from the alkene intermediate during the reaction.
基金
supported by the National Natural Science Foundation of China (22171079)
the Natural Science Foundation of Shanghai (21ZR1480400)
the Shanghai Rising-Star Program (20QA1402300)
the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03)
the Program of Introducing Talents of Discipline to Universities (B16017)
the Fundamental Research Funds for the Central Universities。
