摘要
目的 通过数据挖掘方法研究新安医家治疗咳嗽医案的证候-药物关联规律及组方用药规律,为咳嗽病的治疗提供参考。方法 收集并归纳治疗咳嗽的新安医家医籍医案,使用频次分析、拓扑学分析、Louvain聚类分析方法,对证候、方药进行数据挖掘研究,探讨咳嗽治疗医案中证候与药物的关系及组方规律。结果 共纳入525则医案,共得出风热犯肺证、痰湿蕴肺证、肺气虚证等26种证候;涉及243味药物,频次>70的药物有18味,以性寒、温、平,味甘、苦、辛,入肺经,或性平、温,味甘,入脾胃经药物居多;药物功效类别共25类,以补气药、清热药多见;得出甘草、茯苓、苦杏仁等30味核心药物及核心药物网络;证候-药物聚类分析得出外感咳嗽及内伤咳嗽实证和虚证主要证候的核心药物配伍。结论 新安医家诊治咳嗽病特色鲜明,在止咳化痰及对证治疗的基础上重视“固本培元”“养阴护阴”“培土生金”等方法的运用及经方的继承使用。
Objective To study the syndrome-drug association rule and the medication law of cough medical cases treated by Xin'an doctors using the data mining method;To provide reference for the treatment of cough.Methods The medical records of Xin'an doctors were collected and summarized.The frequency analysis,topology analysis and Louvain clustering analysis were used to conduct data mining research on syndrome types and prescriptions,and the relationship between syndrome types and prescriptions in cough treatment medical records and the law of drug composition in prescriptions were discussed.Results A total of 525 medical cases were included,and 26 kinds of syndromes were obtained,such as wind-heat invading lung,phlegm-dampness holding lung,lung qi deficiency.There were 243 kinds of Chinese materia medica involved,and 18 kinds of Chinese materia medica were with more than 70 times in frequency.The main properties were cold,warm and mild,and the main tastes were sweet,bitter and pungent, mainly in lung meridian, or the main properties were mild and warm and the main taste was sweet,mainly in spleen and stomach meridian. There were 25 categories in efficacy, which were mainly tonics and heatclearingmedicine. 30 core medicines and core medicinal networks were obtained, such as Glycyrrhizae Radix etRhizoma, Poria and Armeniacae Semen Amarum. The core drug combination of main syndromes of exogenous coughand excess syndrome and deficient syndrome of endogenous cough were obtained by syndrome-drug clusteringanalysis. Conclusion Xin'an doctors have distinctive characteristics in the diagnosis and treatment of cough diseases,and pay attention to the use of the methods of “strengthening the basic and promoting original qi”, “nourishing yinand protecting yin”, “cultivating the soil and promoting gold” and the inheritance of the prescriptions on the basis ofcough relieving, phlegm resolving, and syndrome-based treatment.
作者
王卉
丁焕章
杨勤军
杨程
童佳兵
李泽庚
WANG Hui;DING Huanzhang;YANG Qinjun;YANG Cheng;TONG Jiabing;LI Zegeng(Anhui University of Chinese Medicine,Hefei 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China;Institute of Respiratory Diseases,Anhui Academy of Chinese Medicine,Hefei 230031,China;Xin'an Key Laboratory of Medical Science,Ministry of Education,Hefei 230038,China;Key Laboratory of Application and Transformation of Traditional Chinese Medicine in Prevention and Treatment of Major Pulmonary Diseases,Hefei 230031,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2024年第3期34-41,共8页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金区域创新发展联合基金重点支持项目(U20A20398)
安徽省临床医学研究转化专项(202204295107020045)。
关键词
咳嗽
证候
药物
用药规律
证候规律
核心中药
数据挖掘
cough
syndrome
drug
medication law
syndrome law
core Chinese materia medica
data mining
