摘要
目的系统评价常规治疗基础上联合应用硫酸镁辅助治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的有效性。方法通过检索平台PubMed、Web of Science、中国知网(CNKI)及万方数据知识服务平台,纳入对比常规治疗与常规治疗联合硫酸镁治疗SAP疗效差异的随机对照试验(randomized controlled trial,RCT),检索时间限定为建库至2022年7月1日。通过Review Manager 5.4软件进行Meta分析以对患者预后进行评价。结果与常规治疗(禁食禁水、胃肠减压、补液、抗生素治疗、抑制胰酶分泌、维持水、电解质及酸碱平衡)比较,硫酸镁辅助治疗可降低SAP患者相关病死率及并发症发生率,可缩短住院时间、腹痛缓解时间及发热时间。结论常规治疗基础上加用硫酸镁辅助治疗在改善SAP患者病死率、并发症发生率、住院时间、腹痛缓解时间、发热时间方面均优于单纯常规治疗。
Objective To systematically evaluate the efficacy of magnesium sulfate combined with conventional treatment in the treatment of severe acute pancreatitis(SAP).Methods Randomized controlled trial(RCT)comparing the efficacy difference between conventional treatment and conventional treatment combined with magnesium sulfate in the treatment of SAP were included by searching PubMed,Web of Science,CNKI and WanFang data knowledge service platform from the establishment of the database to July 1,2022.Meta-analysis was performed by Review Manager 5.4software to evaluate the prognosis of patients.Results Compared with the conventional treatment(water fasting,gastrointestinal decompression,fluid replacement,antibiotic treatment,inhibition of pancreatic enzyme secretion,maintenance of water,electrolyte and acid-base balance),magnesium sulfate combined with conventional treatment can reduce the mortality and complications related to SAP,and shorten the length of hospital stay,relief time of abdominal pain,duration of fever.Conclusion Magnesium sulfate combined with conventional treatment is superior to conventional treatment in improving the mortality,complication rate,length of hospital stay,relief time of abdominal pain,duration of fever in patients with SAP.
作者
滕跃
谭刚
冯皓男
纪道林
TENG Yue;TAN Gang;FENG Haonan(Department of General Surgery,The Fourth Affiliated Hospital,Harbin Medical University,Heilongjiang 150001,China)
出处
《医学研究杂志》
2023年第12期65-70,共6页
Journal of Medical Research
基金
国家自然科学基金青年科学基金资助项目(82102911)
黑龙江省自然科学基金优秀青年项目(YQ2022H011)
哈尔滨医科大学附属第四医院基金特别资助项目(HYDSYTB201919)。
关键词
硫酸镁
重症急性胰腺炎
META分析
治疗结果
循证医学
Magnesium sulfate
Severe acute pancreatitis
Meta-analysis
Treatment outcome
Evidence-based medicine
