摘要
目的 观察强化降脂对急性ST段抬高型心肌梗死介入治疗的影响。方法 选取2021年1月—2022年5月白银市第一人民医院收治的急性ST段抬高型心肌梗死介入治疗患者71例,采用随机数字表法分为试验组36例和对照组35例。对照组给予注射用阿替普酶治疗,试验组在对照组治疗基础上给予阿托伐他汀钙片治疗,2组均连续治疗21 d。比较2组临床疗效,治疗前后心功能指标[左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)]、血脂指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)及三酰甘油(TG)]、血液生化指标[超氧化物歧化酶(SOD)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)]。结果 试验组治疗总有效率为97.22%,高于对照组的77.14%(χ^(2)=4.777,P=0.029)。治疗21 d后,2组LVEF高于治疗前,LVESD、LVEDD小于治疗前,且试验组升高/减小幅度大于对照组(P<0.01);2组LDL-C、TC、TG水平与CK-MB、cTnT水平低于治疗前,HDL-C与SOD水平高于治疗前,且试验组降低/升高幅度大于对照组(P<0.05或P<0.01)。结论 强化降脂可提高急性ST段抬高型心肌梗死介入治疗的临床效果,可有效改善患者心功能,缓解心肌损伤,调节血脂。
Objective To observe the effect of intensive lipid-lowering on interventional therapy for acute ST-segment elevation myocardial infarction.Methods A total of 71 patients with acute ST-segment elevation myocardial infarction admitted to Baiyin First People′s Hospital from January 2021 to May 2022 were selected and divided into the experimental group(36 cases)and the control group(35 cases)by random number table method.The control group was treated with alteplase for injection,and the experimental group was treated with atorvastatin calcium tablets on the basis of the control group.Both groups were treated continuously for 21 days.The clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)],lipid indexes[low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),total cholesterol(TC)and triglyceride(TG)],blood biochemical indexes[superoxide dismutase(SOD),creatine kinase-MB(CK-MB),cardiac troponin T(cTnT)]before and after treatment were compared between the two groups.Results The total effective rate of the experimental group was 97.22%,which was higher than 77.14%of the control group(χ^(2)=4.777,P=0.029).After 21 days of treatment,LVEF in two groups were higher than before treatment,LVESD and LVEDD were lower than before treatment,and the increase/decrease of experimental group were greater than those of control group(P<0.01).The levels of LDL-C,TC,TG,CK-MB and cTnT in two groups were lower than before treatment,and the levels of HDL-C and SOD in experimental group were higher than those of control group(P<0.05 or P<0.01).Conclusion Intensive lipid-lowering can improve the clinical effect of interventional therapy for acute ST-segment elevation myocardial infarction,effectively improve the cardiac function of patients,alleviate myocardial injury,and regulate blood lipids.
作者
赵帅
ZHAO Shuai(Department of Cardiology,The First People′s Hospital of Baiyin,Gansu Province,Baiyin 730900,China)
出处
《临床合理用药杂志》
2024年第4期8-10,21,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
心肌梗死
急性ST段抬高型
强化降脂
介入治疗
Myocardial infarction
Acute ST-segment elevation type
Intensive lipid-lowering
Interventional therapy
