摘要
目的 观察乌灵胶囊联合注射用A型肉毒毒素治疗良性特发性眼睑痉挛(BEB)合并失眠的临床效果及对睡眠质量的影响。方法 选择2018年2月—2021年5月徐州市第一人民医院收治的BEB合并失眠患者60例,采用随机数字表法分为观察者和对照组各30例。对照组给予注射用A型肉毒毒素治疗,观察组在对照组基础上给予乌灵胶囊治疗,治疗时间为6周。比较2组痉挛治疗效果,焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)、世界卫生组织生活质量简表(WHOQOL-BREF)评分及不良反应。结果 观察组总有效率与对照组比较差异无统计学意义(93.33%vs. 86.67%,χ^(2)=0.185,P=0.667)。治疗后4、8周,2组SAS、SDS、PSQI评分均低于治疗前,且观察组低于对照组(P<0.05或P<0.01);治疗后6周,2组WHOQOL-BREF评分均高于治疗前,且观察组高于对照组(P<0.05或P<0.01);观察组与对照组不良反应总发生率比较差异无统计学意义(16.67%vs. 13.33%,P=1.000)。结论 乌灵胶囊联合注射用A型肉毒毒素治疗BEB伴失眠安全有效,能显著改善患者焦虑抑郁程度,提高睡眠及生活质量。
Objective To observe the clinical effect of Wuling capsule combined with botulinum toxin type A injection in the treatment of benign essential blepharospasm(BEB)with insomnia and its effect on sleep quality.Methods A total of 60 BEB patients with insomnia who were admitted to Xuzhou First People′s Hospital from February 2018 to May 2021 were selected and divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The control group was treated with botulinum toxin type A for injection,and the observation group was treated with Wuling capsule on the basis of the control group,the treatment time was 6 weeks.The treatment effect of spasm,self-rating anxiety scale(SAS),self-rating depression scale(SDS),Pittsburgh sleep quality index(PSQI),World Health Organization Quality of Life Brief scale(WHOQOL-BREF)scores and adverse reactions were compared between the two groups.Results There was no significant difference in the total effective rate between the observation group and the control group(93.33%vs.86.67%,χ^(2)=0.185,P=0.667).4 and 8 weeks after treatment,SAS,SDS and PSQI scores of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group(P<0.05 or P<0.01).6 weeks after treatment,the WHOQOL-BREF scores of the two groups were higher than those before treatment,and the scores of the observation group were higher than those of the control group(P<0.05 or P<0.01).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group(16.67%vs.13.33%,P=1.000).Conclusion Wuling capsule combined with botulinum toxin type A for injection is safe and effective in the treatment of BEB with insomnia,which can significantly improve the degree of anxiety and depression,and improve the quality of sleep and life.
作者
刘婧
钱秋晨
何清
秦敬翠
LIU Jing;QIAN Qiuchen;HE Qing;QIN Jingcui(不详;Department of Neurology,Xuzhou First People′s Hospital,Jiangsu Province,Xuzhou 221000,China)
出处
《临床合理用药杂志》
2024年第4期22-25,38,共5页
Chinese Journal of Clinical Rational Drug Use
基金
徐州市卫生健康委青年医学科技创新项目(XWKYHT20210523)
彭城英才—青年医学后备人才培养项目(XWRCHT20220010)。
关键词
良性特发性眼睑痉挛
失眠
乌灵胶囊
A型肉毒毒素
Benign essential blepharospasm
Insomnia
Wuling capsule
Botulinum toxin type A
