摘要
目的探讨尤瑞克林在急性脑梗死治疗中的临床疗效及其对患者神经功能的影响。方法随机选取2021年1月—2023年10月遵义市红花岗区人民医院收治的80例急性脑梗死患者为研究对象,依据随机数表法分为两组,各40例。对照组采取血栓通和银杏叶提取物的常规治疗方案。观察组在此基础上增加了尤瑞克林的治疗方法,比较两组患者的神经功能缺损,脑血液流变学水平、神经因子与炎性因子水平、日常生活活动能力、精神状态。结果治疗后,两组患者的全血高切黏度、全血低切黏度以及右冠状动脉均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组的神经生长因子和神经营养因子水平高于对照组,高敏C反应蛋白、可溶性细胞间黏附分子、炎症因子Toll样受体4低于对照组,差异有统计学意义(P<0.05)。治疗前,两组简易精神状态评分和日常生活活动能力评分比较,差异无统计学意义(P>0.05);治疗后,两组评分都有所提升,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组的临床治疗有效率高于对照组,差异有统计学意义(t=3.914,P<0.05)。结论尤瑞克林在急性脑梗死的治疗中能有效改善脑血液流变学指标、减少炎性因子,提升神经因子水平,进而显著提高患者的神经功能和日常生活活动能力,其疗效优于单纯使用血栓通及银杏叶提取物的常规治疗方案。
Objective To investigate the clinical efficacy of Eurekline in the treatment of acute cerebral infarction and its effect on the neurological function of patients.Methods A total of 80 patients with acute cerebral infarction admitted to Honghuagang District People's Hospital from January 2021 to October 2023 were randomly selected as the research objects.According to the random number table,they were divided into two groups,with 40 cases in each group.The control group was treated with routine treatment of Xueshuantong and Ginkgo biloba extract.On this basis,the observation group increased the treatment of urinary kallidinogenase.The neurological deficits,cerebral hemorheology levels,nerve factors and inflammatory factor levels,activities of daily living,and mental state were compared between the two groups.Results After treatment,the whole blood high shear viscosity,whole blood low shear viscosity and right coronary artery of the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).The levels of nerve growth factor and neurotrophic factor in the observation group were higher than those in the control group,and the levels of high-sensitivity C-reactive protein,soluble intercellular adhesion molecule and inflammatory factor Toll-like receptor 4 were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of simple mental state and activities of daily living between the two groups(P>0.05).After treatment,the scores of the two groups were improved,and the observation group were higher than the control group,the differences were statistically significant(P<0.05).The clinical efficacy in the observation group was higher than that in the control group,the difference was statistically significant(t=3.914,P<0.05).Conclusion In the treatment of acute cerebral infarction,urinary kallidinogenase can effectively improve the indexes of cerebral hemorheology,reduce inflammatory factors,increase the level of nerve factors,and then significantly improve the neurological function and activities of daily living of patients.Its curative effect is better than that of routine treatment with Xueshuantong and Ginkgo biloba extract alone.
作者
晏天娥
汤雪蓉
YAN Tian'e;TANG Xuerong(Department of Neurology,Honghuagang District People's Hospital,Zunyi,Guizhou Province,563000 China)
出处
《中外医疗》
2023年第35期109-113,共5页
China & Foreign Medical Treatment
关键词
尤瑞克林
血栓通
银杏叶提取物
临床疗效
神经功能
Yulicrin
Thrombus Tong
Ginkgo biloba leaf extract
Clinical effect
Neural function
