摘要
目的:探讨紫藤根及含紫藤根经验方的抗炎、镇痛作用及其药效动力学规律。方法:通过小鼠棉球肉芽肿炎症实验研究紫藤根及含紫藤根经验方的慢性增生性抗炎作用,同时通过小鼠扭体实验探索紫藤根及含紫藤根习用经验方的镇痛作用。结果:紫藤根及含紫藤根经验方3个剂量组均能不同程度地抑制肉芽的生长,对于棉球肉芽肿所引起的慢性炎症有抑制作用;同时,此方各剂量组均有极显著的镇痛作用。结论:验证了紫藤根及含紫藤根经验方的抗炎、镇痛效果,同时诠释了其经验方所占配伍比例偏少会使整个经验方的抗炎、镇痛效果更好,此研究能为紫藤根的质量标准与临床应用提供参考。
Objective:To investigate the anti-inflammatory and analgesic effects of Ziteng root and its empirical formula containing Ziteng root,as well as their pharmacokinetic patterns.Methods:The chronic proliferative anti-inflammatory effect of Wisteria vine root and empirical formula containing Wisteria vine root was studied by cotton ball Granuloma inflammation experiment in mice,and the analgesic effect of Wisteria vine root and empirical formula containing Wisteria vine root was explored by writhing test in mice.Results:The three dose groups of Wisteria vine root and empirical formula containing Wisteria vine root could inhibit the growth of granulation in different degrees,and inhibit the chronic inflammation caused by cotton ball Granuloma;At the same time,all dosage groups of this formula have extremely significant analgesic effects.Conclusion:To verify the anti-inflammatory and analgesic effects of Ziteng root and empirical formulas containing Ziteng root,and to explain that a small proportion of its empirical formula will have a better anti-inflammatory and analgesic effect on the entire empirical formula.This study provides a reference for the quality standards and clinical application of Ziteng root.
作者
罗健菱
胡家震
唐娟
邓斌
马彬焰
邰通芝
胡成刚
Luo Jian-ling;Hu Jia-zhen;Tang Juan;Deng Bin;Ma Bin-yan;Tai Tong-zhi;Hu Cheng-gang(Guizhou University of Traditional Chinese Medicine,Guiyang Guizhou 550025,China)
出处
《江西化工》
CAS
2024年第1期78-83,共6页
Jiangxi Chemical Industry
基金
国家中医药管理局项目(3040-040180043)。
关键词
紫藤根及含紫藤根经验方
抗炎作用
镇痛作用
药理研究
wisteria root and empirical formula containing wisteria root
Anti inflammatory effects
Analgesic effect
Pharmacological research
