摘要
原发性膜性肾病血栓形成的风险较高,血栓形成通常发生在病程早期。血栓的形成与多种因素相关,目前普遍认为低蛋白血症为其独立风险因素,其他风险因素包括蛋白尿、M型磷脂酶A2受体抗体、D-二聚体等。虽然预防性抗凝被认为是原发性膜性肾病的一般支持治疗,但目前在时机选择、血清白蛋白阈值确定以及治疗方案制定等方面仍存在争议。该文对上述问题相关文献进行综述,以期为形成该类患者血栓防治标准提供参考,为临床实践提供参考。
Patients with primary membranous nephropathy(PMN)tend to develop thrombosis,especially in the early phase of the disease.The pathogenesis of thrombosis is multifactorial,with hypoalbuminemia being widely regarded as an independent risk factor.Other factors include proteinuria,M-type phospholipase A2 receptor antibody,and D-dimer.Although prophylactic anticoagulation therapy is frequently used in clinical practice to prevent thrombosis in PMN patients,there are still many unresolved issues regarding the optimal prevention of thrombosis in this condition.The timing of prophylactic anticoagulation,the threshold of serum albumin level,and the choice of treatment regimen are still lacking consensus.This article reviewed the relevant literature on these topics,aiming to establish a standard for thrombosis prevention and treatment for this population in the future and provide guidance for clinical practice.
作者
李炼
郑星月
武刘芸
尹琪楠
韩丽珠
雷洋
边原
LI Lian;ZHENG Xingyue;WU Liuyun;YIN Qinan;HAN Lizhu;LEI Yang;BIAN Yuan(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;Department of Pharmacy&Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Provincial People's Hospital/Affiliated Hospital of University of Electronic Science and Technology of China,Sichuan Academy of Medical Sciences,Chengdu 610072,China)
出处
《医药导报》
CAS
北大核心
2024年第3期418-423,共6页
Herald of Medicine
基金
国家重点研发计划(2020YFC2005500)
四川省科技厅自然科学基金资助项目(2019YFS0514,2022NSFSC0818)
个体化药物治疗四川省重点实验室开放课题(2021ZD01)
四川省干部保健科研课题(川干研ZH2021-20)。
关键词
原发性膜性肾病
血栓栓塞
预防性抗凝
血清白蛋白
Primary membranous nephropathy
Thromboembolism
Preventive anticoagulation
Serum albumin
