摘要
目的 探讨自拟外洗方治疗尿毒症性皮肤瘙痒症(UP)病人的疗效。方法 选取苏州市中西医结合医院2019年4月至2020年4月收治的UP病人86例,按随机数字表法分为观察组和对照组,每组各43例。两组均采取常规透析疗法,对照组采用瘙痒部位外涂炉甘石洗剂治疗,观察组采用自拟外洗方进行药浴,疗程4周。比较两组治疗前与治疗4周、随访至12周的瘙痒程度[采用四项目瘙痒量表(FIIQ)评估]、生活质量[采用生活质量综合评定问卷-74(GQOL-74)评估]与睡眠质量[采用匹兹堡睡眠质量指数(PSQI)评估]及血钙、血磷、全段甲状旁腺激素(iPTH)、C反应蛋白(CRP)、白细胞介素-31(IL-31)、血β2-微球蛋白(β2-MG)水平。结果 对照组和观察组治疗前的FIIQ评分为(11.23±1.89)分和(11.07±1.72)分,治疗4周分别降低至(6.17±1.58)分和(4.68±1.11)分,随访至12周为(6.54±1.64)分和(4.77±1.36)分,组间比较、时间点比较及交互作用的差异有统计学意义(P<0.001)。两组病人GQOL-74评分、PSQI评分、血磷、iPTH、血清CRP、IL-31、β2-MG的组间比较、时间点比较及交互作用的差异有统计学意义(P<0.001)。血钙的组间比较、时间点比较及交互作用的差异无统计学意义(P>0.05)。结论 自拟外洗方治疗UP可有效缓解病人瘙痒症状,降低血清CRP、IL-31、β2-MG水平,提高睡眠质量与生活质量。
Objective To investigate the therapeutic effect of self-designed external washing prescription on uremic pruritus(UP).Methods A total of 86 patients with UP admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from April 2019 to April 2020 were selected and divided into observation group and control group by random number table method,with 43cases in each group.The two groups were treated with routine dialysis therapy,the control group was treated with calamine lotion applied to the pruritus,and the observation group was treated with self-designed prescription for external washing.The course of treatment was 4 weeks.The degree of pruritus [measured by four-item Itch Scale(FIIQ)],quality of life [measured by Generic Quality of Life Inventory-74(GQOL-74)],sleep quality [measured by Pittsburgh Sleep Quality Index(PSQI)],blood calcium,blood phosphorus and intact parathyroid hormone(iPTH),C-reactive protein(CRP),interleukin-31(IL-31),and blood β2-microglobulin(β2-MG) levels after 4weeks of treatment and follow-up to 12 weeks were compared between the two groups.Results The FIIQ scores before treatment in the control group and the observation group were(11.23±1.89) points and(11.07±1.72) points,which decreased to(6.17±1.58) points and(4.68±1.11) points at 4 weeks of treatment,respectively,and were(6.54±1.64) points and(4.77±1.36) points at 12 weeks of follow-up,and there were significant differences between groups,time point comparison and interaction(P<0.001).There were significant differences in GQOL-74 score,PSQI score,blood phosphorus,iPTH,serum CRP,IL-31,β2-MG between groups,time point comparison and interaction(P<0.001).There were no significant difference between groups,time point comparison and interaction of blood calcium(P>0.05).Conclusion The self-designed external washing formula can effectively relieve pruritus symptoms in patients with UP,reduce serum CRP,IL-31,β2-MG levels,and improve sleep quality and quality of life.
作者
毛毅晶
朱惠军
蒋毅
MAO Yijing;ZHU Huijun;JIANG Yi(Department of Nephrology,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou,Jiangsu 215101,China)
出处
《安徽医药》
CAS
2024年第3期613-617,共5页
Anhui Medical and Pharmaceutical Journal
基金
江苏省中医药局科技项目(YB2020059)
苏州市中西医结合医院院级课题(YJ2018014)。
关键词
尿毒症
瘙痒症
浴疗学
自拟外洗方
生活质量
炎症反应
血Β2-微球蛋白
Uremia
Pruritus
Balneology
Self-made external washing prescription
Quality of life
Inflammatory response
Bloodβ2-microglobulin
