摘要
目的 通过探究上呼吸道感染后嗅觉障碍脑灰质形态变化,得出上呼吸道感染后嗅觉障碍患者嗅觉中枢结构的影像学特点。方法 选取上呼吸道感染后嗅觉障碍的患者24例与嗅觉功能正常的健康对照受试者20例,通过基于体素的大脑皮质形态学体积测量(VBM)比较患者的大脑灰质和白质体积与对照组的差异。结果 上呼吸道感染后嗅觉障碍组患者TDI[气味察觉阈(T)、气味辨别能力(D)、气味识别能力(I)]总分(16.45±5.62)分,T为(2.33±0.93)分,D为(6.54±2.60)分,I为(7.58±3.22)分;嗅觉障碍平均时长为(19.00±6.33)个月;视觉模拟量表评分(VAS)为(7.79±2.41)分,与对照组比较均存在统计学差异(P<0.05)。上呼吸道感染后嗅觉障碍患者的大脑灰质总体积和嗅皮质体积明显小于对照组(P<0.05),大脑灰质总体积占全脑体积的比例和皮质厚度与嗅觉功能评分TDI值呈正相关(r=0.71,P<0.000 1;r=0.69,P=0.000 9)。结论 上呼吸道感染后嗅觉障碍患者大脑灰质总体积和嗅皮质体积减少,且嗅觉功能与大脑灰质体积比例及皮质厚度呈正相关。
Objective To explore the morphological changes of gray matter in patients with olfactory dysfunction following upper respiratory tract infections,and obtain the imaging characteristics of olfactory center structure in patients with post-infectious olfactory dysfunction.Methods Twenty-four patients with post-infectious olfactory dysfunction(OD group)and 20 healthy subjects(control group)with normal olfactory function were selected.Voxel-based cortical morphometry was used to compare the volume of gray matter and white matter between the two groups.Results Of the OD group,the total ordor threshold,discrimination and identification(TDI)score was 16.45±5.62,while the threshold(T)score was 2.33±0.93,the discrimination(D)score was 6.54±2.60,and the identification(I)score was 7.58±3.22,the average duration of olfactory dysfunction was(19.00±6.33)months,and the visual analogue scale(VAS)score was 7.79±2.41.The differences of above-mentioned indexes between the OD group and the control group were all statistically significant(P<0.05).The total gray matter volume and olfactory cortex volume of the OD group were significantly smaller than those of the control group(P<0.05).The proportion of total gray matter volume to total brain volume and cortical thickness were positively correlated with olfactory function TDI score(r=0.71,P<0.0001;r=0.69,P=0.0009).Conclusion Patients with post-infectious olfactory dysfunction have decreased gray matter volume and olfactory cortex volume,and olfactory function is positively correlated with gray matter volume ratio and cortical thickness.
作者
许尧珂
孟祥主
于辉
王佳悦
邱继宽
李瑞
范宝石
刘俊秀
XU Yaoke;MENG Xiangzhu;YU hui;WANG Jiayue;QIU Jikuan;LI Rui;FAN Baoshi;LIU Junxiu(Department of Otorhinolaryngology,Peking University Third Hospital,Beijing 100191,China;Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China)
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
CSCD
2024年第1期71-76,共6页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金
科技创新2030—“新一代人工智能”重大项目(2018AAA0102101,2020AAA0109602)。
关键词
嗅觉障碍
上呼吸道感染后嗅觉障碍
上呼吸道感染
基于体素的形态学分析
Olfactory dysfunction
Post-infectious olfactory dysfunction
Upper respiratory tract infection
Voxel-based morphometry
