摘要
目的探讨坦索罗辛胶囊联合前列舒通治疗老年良性前列腺增生(BPH)伴下尿路症状的有效性与耐受性。方法选取2019年1月至2022年12月宿松县人民医院收治的82例老年BPH伴下尿路症状患者作为研究对象。采用随机数字表法分为对照组(n=41)和观察组(n=41)。对照组采用坦索罗辛胶囊治疗,观察组在对照组基础上联合前列舒通胶囊治疗。治疗8周后,比较两组的国际前列腺症状评分(IPSS)、前列腺体积、尿动力学指标[残余尿量(PVR)、平均尿流率(AFR)及最大尿流率(MFR)]、实验室指标[前列腺特异性抗原(PSA)、尿沉渣红细胞数]及不良反应发生情况。结果治疗后,两组IPSS均降低、前列腺体积均缩小(P<0.05),且观察组IPSS评分低于对照组、前列腺体积小于对照组(P<0.05);治疗后,两组AFR、MFR均升高、PVR均降低(P<0.05),且观察组AFR、MFR高于对照组、PVR低于对照组(P<0.05);治疗后,两组PSA、尿沉渣红细胞数均下降(P<0.05),且观察组的PSA、尿沉渣红细胞数均低于对照组(P<0.05);治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论坦索罗辛胶囊联合前列舒通可有效改善老年BPH患者的病情,减轻下尿路症状,改善尿动力学指标,且药物耐受性及安全性值得肯定。
Objective To explore the effectiveness and tolerance of tamsulosin capsules combined with Qianlie Shutong capsules in the treatment of elderly benign prostatic hyperplasia(BPH)with lower urinary tract symptoms.Methods A total of 82 elderly BPH patients with lower urinary tract symptoms admitted to the People′s Hospital of Susong from January 2019 to December 2022 were selected as the research subjects.They were divided into control group(n=41)and observation group(n=41)by the random number table method.The control group was treated with tamsulosin capsules while the observation group was treated with Qianlie Shutong capsules on the basis of the control group.After 8 weeks of treatment,international prostate symptom score(IPSS),prostate volume,urodynamic indicators[post-voiding residual(PVR),average urinary flow rate(AFR),and maximum urinary flow rate(MFR)],laboratory indicators[prostate specific antigen(PSA),urinary sediment erythrocyte count]and occurrence of adverse reactions were compared between the two groups.Results After treatment,the IPSS in both groups decreased,the prostate volume reduced(P<0.05),and the IPSS in observation group was lower than that in control group,the prostate volume was smaller than that in control group(P<0.05).After treatment,the AFR and MFR in both groups were increased while the PVR was decreased(P<0.05),and the AFR and MFR in observation group were higher than those in control group while the PVR was lower than that in control group(P<0.05).After treatment,the PSA and urinary sediment erythrocyte count were decreased in the two groups(P<0.05),and the PSA and urinary sediment erythrocyte count in observation group were lower than those in control group(P<0.05).During treatment,there were no significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusions Tamsulosin capsules combined with Qianlie Shutong capsules can effectively improve the disease condition of elderly BPH patients,reduce the lower urinary tract symptoms and improve the urodynamics,and its drug tolerance and safety are worthy of approval.
作者
俞沁珏
肖卫国
余运康
YU Qinjue;XIAO Weiguo;YU Yunkang(Department of Pharmacy,the People′s Hospital of Susong,Susong 236500,Anhui,China)
出处
《中国性科学》
2024年第2期33-37,共5页
Chinese Journal of Human Sexuality
关键词
坦索罗辛胶囊
前列舒通
良性前列腺增生
下尿路症状
有效性
Tamsulosin capsules
Qianlie Shutong capsules
Benign prostatic hyperplasia
Lower urinary tract symptoms
Effectiveness
