摘要
目的:分析新生儿先天性甲状腺功能减退症发生的影响因素。方法:选取2019年1月至2023年1月于该院出生的215例新生儿进行横断面研究,收集新生儿的临床资料和孕母资料,根据是否发生先天性甲状腺功能减退症将其分为发生组和未发生组,采用Logistic回归分析新生儿先天性甲状腺功能减退症发生的影响因素。结果:215例新生儿中,发生先天性甲状腺功能减退症105例,发生率为48.84%(105/215);两组性别、孕母孕次、孕母产次、合并妊娠期高血压、合并妊娠期糖尿病比较,差异均无统计学意义(P>0.05);发生组出生胎龄<37周、出生体质量<2.5 kg、胎儿宫内窘迫、孕母年龄≥35岁、孕期存在焦虑情绪、有甲状腺疾病家族史、有孕期重金属接触史占比均高于未发生组,有孕期黄体酮用药史占比低于未发生组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,出生胎龄<37周、出生体质量<2.5 kg、胎儿宫内窘迫、孕母年龄≥35岁、孕期存在焦虑情绪、有甲状腺疾病家族史、有孕期重金属接触史均为新生儿先天性甲状腺功能减退症发生的危险因素(OR>1,P<0.05),有孕期黄体酮用药史为新生儿先天性甲状腺功能减退症发生的保护因素(OR<1,P<0.05)。结论:出生胎龄<37周、出生体质量<2.5 kg、胎儿宫内窘迫、孕母年龄≥35岁、孕期存在焦虑情绪、有甲状腺疾病家族史、有孕期重金属接触史均为新生儿先天性甲状腺功能减退症发生的危险因素,有孕期黄体酮用药史为新生儿先天性甲状腺功能减退症发生的保护因素。
Objective:To analyze influencing factors of neonatal congenital hypothyroidism.Methods:A cross-sectional study was conducted on 215 neonates born in the hospital from January 2019 to January 2023.The neonatal clinical data and the maternal data were collected.According to whether congenital hypothyroidism occurred,they were divided into occurrence group and non-occurrence group.Logistic regression was used to analyze the influencing factors of neonatal congenital hypothyroidism.Results:Among the 215 neonates,105 had congenital hypothyroidism,with an incidence of 48.84%(105/215).There were no significant differences between the two groups in gender,gravidity,parity,gestational hypertension and gestational diabetes mellitus(P>0.05).The proportions of the neonates with gestational age<37 weeks,birth weight<2.5 kg,fetal distress,maternal age≥35 years old,anxiety during pregnancy,family history of thyroid disease,and history of heavy metal exposure during pregnancy in the occurrence group were higher than those in the non-occurrence group;the proportion of progesterone medication history during pregnancy was lower than that in the non-occurrence group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that gestational age<37 weeks,birth weight<2.5 kg,fetal distress,maternal age≥35 years old,anxiety during pregnancy,family history of thyroid disease,and history of heavy metal exposure during pregnancy were all risk factors for neonatal congenital hypothyroidism(OR>1,P<0.05),and the history of progesterone medication during pregnancy was a protective factor(OR<1,P<0.05).Conclusions:Gestational age<37 weeks,birth weight<2.5 kg,fetal distress,maternal age≥35 years old,anxiety during pregnancy,family history of thyroid disease,and history of heavy metal exposure during pregnancy are the risk factors for neonatal congenital hypothyroidism,and the history of progesterone medication during pregnancy is the protective factor.
作者
赵艳平
ZHAO Yanping(Premature Infant Ward of Henan Children’s Hospital,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2024年第3期5-8,共4页
Medical Journal of Chinese People’s Health
