摘要
目的探讨血小板平均体积(mean platelet volume,MPV)和D-二聚体与类风湿关节炎(rheumatoid arthritis,RA)疾病程度的关系。方法选取2021年1月至12月就诊于萍乡市人民医院的120例RA患者,检测并分析患者治疗前后MPV、D-二聚体和C-反应蛋白(C-reactive protein,CRP)水平。结果患者治疗前后的MPV、D-二聚体和CRP水平比较,差异有统计学意义(P<0.05)。MPV、D-二聚体和CRP联合检测与疾病进展符合率为99.17%,高于单一项目检测(MPV、D-二聚体、CRP单一检测符合率分别为90.83%、91.67%、91.67%)。结论RA患者活动期MPV降低,与活动程度呈负相关;D-二聚体和CRP水平升高,与活动程度呈正相关。三者联合检测可提高RA疾病进展的阳性诊断率。MPV和D-二聚体可作为RA病情评估的新的生物学标志物,临床可参考其值预测疾病的发展和活动度。
Objective To explore the relationship between mean platelet volume(MPV)and D-dimer with the severity of rheumatoid arthritis(RA).Methods A total of 120 RA patients who visited Pingxiang People’s Hospital from January to December 2021 were selected to detect and analyze the levels of MPV,D-dimer,and C-reactive protein(CRP)before and after treatment.Results The differences in MPV,D-dimer,and CRP levels before and after treatment were statistically significant(P<0.05).The coincidence rate between the combined detection of MPV,D-dimer,and CRP and disease progression was 99.17%,which was higher than that of single item detection(the coincidence rates of MPV,D-dimer,and CRP single detection were 90.83%,91.67%,and 91.67%,respectively).Conclusion MPV was reduced during active phase in RA patients,it’s negatively correlated with activity level;D-dimer and CRP were elevated and positively correlated with activity level.Combined detection of the three can improve the positive diagnostic rate of RA disease progression.MPV and D-dimer can serve as new biological markers for evaluating the condition of RA diseases,so its value can be used in clinical practice to predict the development and activity of diseases.
作者
杨剑
陈玲
廖洁
YANG Jian;CHEN Ling;LIAO Jie(Department of Clinical Laboratory,Pingxiang People’s hospital,Pingxiang 337055,Jiangxi,China)
出处
《中国现代医生》
2024年第6期51-53,72,共4页
China Modern Doctor
