摘要
目的:分析奥氮平治疗精神分裂症的效果。方法:选取2023年1—10月南通市紫琅医院精神科收治的精神分裂症患者60例作为研究对象,依据随机数字表法分为两组,各30例。对照组采用氯丙嗪治疗,观察组采用奥氮平治疗。比较两组临床疗效。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.019)。治疗前,两组阳性与阴性精神症状评定量表(PANSS)、简明精神病量表(BPRS)及蒙特利尔认知评估量表(MoCA)评分比较,差异无统计学意义(P>0.05);治疗后,两组PANSS、BPRS评分低于治疗前,且观察组低于对照组,两组MoCA评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.037)。结论:奥氮平治疗精神分裂症的效果较好,可改善患者认知功能与精神症状,且不良反应少。
Objective:To analyze the effects of olanzapine in the treatment of schizophrenia.Methods:A total of 60 patients with schizophrenia admitted to the Psychiatric Department of Nantong Zilang Hospital from January to December 2023 were selected as the study subjects.They were divided into two groups by random number table method,with 30 cases in each group.The control group was treated with chlorpromazine,and the observation group was treated with olanzapine.The clinical efficacy of the two groups was compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.019).Before treatment,there was no significant difference in the scores of the Positive and Negative Symptom Scale(PANSS),the Brief Psychiatric Rating Scale(BPRS)and the Montreal Cognitive Assessment(MoCA)between the two groups(P>0.05);After treatment,the scores of PANSS and BPRS in the two groups were lower than those before treatment,and the scores of PANSS and BPRS in the observation group were lower than those in the control group,while the MoCA scores in the two groups were higher than those before treatment,and the MoCA scores in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.037).Conclusion:Olanzapine is effective in the treatment of schizophrenia,and can improve cognitive function and psychiatric symptom of patients,with few adverse reactions.
作者
吴霞
冯晓慧
胡立红
曹翔
Wu Xia;Feng Xiaohui;Hu Lihong;Cao Xiang(Nantong Zilang Hospital,Nantong 226000,Jiangsu Province,China)
出处
《中国社区医师》
2024年第1期30-32,共3页
Chinese Community Doctors
关键词
奥氮平
精神分裂症
氯丙嗪
Olanzapine
Schizophrenia
Chlorpromazine
