摘要
目的:分析耐碳青霉烯类药物铜绿假单胞菌(carbapenem-resistant pseudomonas aeruginosa,CRPA)在临床科室的分布情况,总结其耐药特点,探讨抗菌方法。方法:选取2022年3月~2023年2月CRPA菌株80株,设为观察组,采集同期不耐碳青霉烯类药物铜绿假单胞菌80株,设为对照组,比较临床科室分布情况、CRPA耐药特点、MBL表型阳性率与基因检测结果。结果:临床分布比较,呼吸与危重症医学科、重症医学科与普外科CRPA检出率较高,差异显著(P<0.05);CRPA耐药特点显示,CRPA对替卡西林/克拉维酸耐药率显著高于其他药物,耐药率较低的常用抗菌药是阿米卡星与妥布霉素;MBL表型阳性率较高,为92.50%(74/80),MDR-PA占比53.75%(43/80),XDR-PA占比22.50%(18/80)。结论:CRPA较易发生在呼吸与危重症医学科和重症医学科,阿米卡星与妥布霉素等药物在CRPA感染中抗菌效果较好,CRPA抗感染治疗中应针对性用药。
Objective:To analyze the distribution of carbapenem-resistant pseudomonas aeruginosa(CRPA)in clinical departments,summarize the characteristics of drug resistance,and explore the antimicrobial methods.Methods:A total of 80 CRPA strains from March 2022 to February 2023 were selected as the observation group,and 80 carbapenem-resistant Pseudomonas aeruginosa strains from the same period were collected as the control group.The distribution of clinical departments,the characteristics of CRPA resistance,the positive rate of MBL phenotype and the results of gene detection were compared.Results:The detec-tion rate of CRPA was higher in the departments of respiratory and critical care medicine,critical care medicine and general surgery,and the difference was statistically significant(P<0.05).The resistance rate of CRPA to ticarcillin/clavulanic acid was significantly higher than that to other antibiotics.Amikacin and tobramycin were the most common antibiotics with low resistance rate.The positive rate of MBL phenotype was 92.50%(74/80),MDR-PA accounted for 53.75%(43/80),and XDR-PA accounted for 22.50%(18/80).Conclusion:CRPA is more likely to occur in the departments of respiratory and critical care medicine and critical care medicine.Amikacin and tobramycin have good antibacterial effects in CRPA in-fection.
作者
肖新荣
王福安
王曼雅
XIAO Xin-rong;WANG Fu-an;WANG Man-ya(Department of Clinical Laboratory,Shishi City Hospital,Shishi,362700,China)
出处
《神经药理学报》
2023年第5期38-42,共5页
Acta Neuropharmacologica
关键词
铜绿假单胞菌
耐药特点
临床分布
感染防控
pseudomonasaeruginosa
drugresistancecharacteristics
clinical distribution
prevention and control of infection
