摘要
目的 探讨肺癌患者放疗前后血清胃泌素释放肽前体(ProGRP)、鳞状细胞癌抗原(SCC)和铁蛋白(SF)水平变化及其临床意义。方法 选取122例非小细胞肺癌(NSCLC)患者作为研究组,根据放疗敏感性分为敏感组(n=43)及不敏感组(n=79)。另选取同期70例健康体检者作为对照组,检测并比较所有受试者血清ProGRP、SCC及SF水平,分析血清ProGRP、SCC及SF水平对NSCLC的诊断价值,并比较NSCLC患者放疗前后血清ProGRP、SCC及SF水平,分析不同放疗敏感性NSCLC患者放疗前后血清ProGRP、SCC及SF水平变化。结果 研究组血清ProGRP、SCC及SF水平均高于对照组(P<0.05);由ROC曲线可知,血清ProGRP、SCC及SF水平联合诊断NSCLC的AUC为0.926,高于三者单独诊断的0.784、0.822、0.805(P<0.05);NSCLC患者放疗后血清ProGRP、SCC及SF水平均低于放疗前(P<0.05);敏感度组放疗后血清ProGRP、SCC及SF水平低于放疗前及不敏感组(P<0.05)。结论 NSCLC患者血清ProGRP、SCC及SF水平升高,三者联合检测对NSCLC具有较高的诊断价值,监测三者水平变化有利于评估NSCLC患者放疗敏感性。
Objective To explore the changes and clinical significance of serum progastrin-releasing peptide(ProGRP),squamous cell carcinoma antigen(SCC)and ferritin(SF)in patients with lung cancer before and after radiotherapy.Methods A total of 122 patients with non-small cell lung cancer(NSCLC)were enrolled as the study group.According to radiotherapy sensitivity,they were divided into sensitivity group(n=43)and non-sensitivity group(n=79).A total of 70 healthy controls during the same period were enrolled as the control group.The levels of serum ProGRP,SCC and SF in all objects were detected and compared,and their diagnostic value for NSCLC was analyzed.The levels of serum ProGRP,SCC and SF in NSCLC patients were compared before and after radiotherapy.The changes of serum ProGRP,SCC and SF before and after radiotherapy in NSCLC patients with different radiotherapy sensitivity were analyzed.Results The levels of ProGRP,SCC and SF in the study group were higher than those in the control group(P<0.05).ROC curves showed that AUC of serum ProGRP combined with SCC and SF in the diagnosis of NSCLC was 0.926,greater than that of single index(0.784,0.822,0.805,P<0.05).After radiotherapy,levels of serum ProGRP,SCC and SF were decreased in NSCLC patients(P<0.05).After radiotherapy,levels of serum ProGRP,SCC and SF were decreased in sensitivity group,which were lower than those in non-sensitivity group(P<0.05).Conclusion The levels of serum ProGRP,SCC and SF increase in NSCLC patients.The combined detection of the three indexes has high diagnostic value for NSCLC,and monitoring their changes is beneficial to evaluate radiotherapy sensitivity of NSCLC patients.
作者
苌哲宗
王耀飞
孟盈君
任原珍
CHANG Zhezong;WANG Yaofei;MENG Yingjun(General Hospital of Pingmei Shenma Group,Pingdingshan,467000)
出处
《实用癌症杂志》
2024年第3期382-385,共4页
The Practical Journal of Cancer
关键词
肺癌
放疗
胃泌素释放肽前体
鳞状细胞癌抗原
铁蛋白
放疗敏感性
Lung cancer
Radiotherapy
Progastrin-releasing peptide
Squamous cell carcinoma antigen
Ferritin
Radiotherapy sensitivity
