摘要
稳态医学这一概念的提出,助力学界从全新的维度理解外界环境复杂、内部改建活跃的牙周组织。牙周区域免疫受复杂的局部刺激持续激活,与上皮屏障、软组织细胞外基质、骨耦联系统产生复杂的交互作用,共同塑造了牙周稳态。生理条件下,适度的区域免疫依靠屏障功能、固有免疫细胞控制菌群,维持稳态。病理条件下,失衡菌群通过中性粒细胞、辅助性T细胞17和B细胞等过度激活的区域免疫推动牙周稳态失衡,引起牙周炎。本文以最基本的免疫学分类为框架,系统概述了区域免疫调控牙周稳态的机制,回顾了靶向区域免疫稳态重塑策略的探索与转化研究,并提出值得挖掘的牙周稳态医学研究方向和潜在的稳态重塑新靶点、新策略。
The concept of homeostatic medicine has helped the researchers to understand the periodontal tissues in a completely new dimension.Periodontal tissues are subjected to complex external environmental stimuli and the internal tissues are continuously undergoing active remodeling.Periodontal regional immunity is continuously activated by local stimuli and interacts with the epithelial barrier,stromal tissue/extracellular matrix,and bone-coupled systems in a complex manner.Together,this complex network shapes the periodontal homeostasis.Under physiological conditions,moderate regional immunity relies on barrier function,intrinsic immune cells to control periodontal microbiota and maintain homeostasis.Under pathological conditions,pathogenic microbiota drive the periodontal homeostasis imbalance through over-activated regional immunity such as neutrophils,helper T(Th)17 cells and B cells,causing periodontitis.Using the most basic immunological classification as a framework,this paper provides a systematic overview of the above mechanisms by which regional immunity regulates periodontal homeostasis,reviews the translational studies that have been carried out on homeostatic remodeling strategies targeting regional immunity,and proposes a series of periodontal homeostasis medicine research directions worth exploring,as well as potential new targets and strategies for homeostatic remodeling.
作者
王志勇
陈谦明
Wang Zhiyong;Chen Qianming(Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine&Clinical Research Center for Oral Diseases of Zhejiang Province&Key Laboratory of Oral Biomedical Research of Zhejiang Province&Cancer Center of Zhejiang University,Hangzhou 310006,China)
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2024年第2期130-137,共8页
Chinese Journal of Stomatology
基金
国家自然科学基金(81991500,81991502)
国家重点研发计划(2022YFC2402900)
浙江省重点研发计划(2021C03074)
国家卫生健康委科学研究基金-浙江省卫生健康重大科技计划(WKJ-ZJ-2212)。
关键词
牙周炎
牙周稳态
区域免疫
屏障功能
稳态重塑治疗
Periodontitis
Periodontal homeostasis
Regional immunity
Barrier function
Homeostatic remodeling therapy
