摘要
N6-甲基腺苷(m6A)修饰是一种常见的表观遗传学修饰,动态调控RNA代谢的整个过程。m6A包括甲基转移酶、去甲基酶及m6A结合蛋白。m6A的甲基化修饰通过调节RNA的衰变、运输、剪切、翻译来调节细胞的增殖和分化,m6A与妇科恶性肿瘤的发生发展有关。笔者就近年来m6A甲基化修饰在宫颈癌、子宫内膜癌和卵巢癌中的相关研究进展进行回顾,分析m6A通过作用于RNA的修饰调节妇科恶性肿瘤发生发展的机制,为妇科恶性肿瘤的治疗、改善预后提供新的方向。
N6-methyladenosine(m6A)modification is a common epigenetic modification that dynamically regulates the entire process of RNA metabolism.m6A includes methyltransferase,demethylase and m6A binding protein.The methylation modification of m6A regulates cell proliferation and differentiation by regulating RNA decay,transport,shear and translation,and m6A is related to the occurrence and development of gynecological malignant tumors.We reviewed the recent research progress of m6A methylation modification in cervical cancer,endometrial cancer and ovarian cancer,and analyzed the mechanism by which m6A regulates the occurrence and development of gynecological malignant tumors through RNA modification,thus providing a new direction for the treatment of gynecological malignant tumors and improving the prognosis.
作者
张海花
雷燕
刘宇
唐松
王露
姚冬梅
ZHANG Haihua;LEI Yan;LIU Yu;TANG Song;WANG Lu;YAO Dongmei(Medical College,Wuhan University of Science and Technology,Wuhan 430070,China;Hubei Maternal and Child Health Care Hospital,Wuhan 430070,China;Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《临床误诊误治》
CAS
2024年第1期147-152,共6页
Clinical Misdiagnosis & Mistherapy
