摘要
2型糖尿病(T2DM)代谢异常可造成中枢神经系统的损害,从而导致认知功能下降。神经丝轻链蛋白(NFL)作为神经元轴突损伤的血液标志物,与认知功能障碍发病显著相关,并受肾功能的影响,可通过炎症反应、血脑屏障的破坏、小胶质细胞和神经元的交互作用、Tau蛋白磷酸化等参与T2DM认知功能障碍的发生发展。本文将对NFL参与T2DM认知障碍发生发展的病理生理机制和NFL与T2DM肾功能的相关性进行综述,为早期诊断和治疗T2DM患者认知功能障碍提供依据。
Metabolic abnormality in type 2 diabetes mellitus(T2DM)can cause damage to the central nervous system,leading to cognitive decline.Neurofilament light chain protein(NFL),as a blood marker of neuroaxonal injuries,is significantly associated with the onset of cognitive impairment and affected by the renal function.It can participate in the development of cognitive impairment in T2DM through inflammation,blood-brain barrier breakdown,interaction between microglia and neurons,and Tau protein phosphorylation.We reviewed the mechanism of the occurrence and development of NFL-involved cognitive impairment and the correlation between NFL and renal function in T2DM,hoping to provide a basis for early diagnosis and treatment of cognitive impairment in T2DM patients.
作者
曹晴祎
田毅
王金浓
CAO Qingyi;TIAN Yi;WANG Jinnong(Department of Anesthesiology,Affiliated Haikou Hospital,Central South University Xiangya School of Medicine,Haikou 570100,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2024年第1期98-103,共6页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81660195)
海南省自然科学基金(821RC724)
海南省卫生健康行业科研项目(22A200301)。
关键词
2型糖尿病
认知功能障碍
神经丝轻链蛋白
type 2 diabetes mellitus
cognitive impairment
neurofilament light chain protein
