摘要
目的探讨丹参片联合那屈肝素钙注射液对髋部骨折术后下肢静脉血流参数的影响。方法将2021年12月至2022年12月接受髋部骨折手术治疗的108例患者作为研究对象,按随机数字表法分为对照组和观察组,每组54例,2组均在术后开始用药,对照组采用那屈肝素钙注射液治疗,观察组采用丹参片联合那屈肝素钙注射液治疗,2组均治疗7 d后,对比术前及术后7 d患肢小腿直径差,对比术前及术后7 d疼痛分级(NRS)、下肢静脉血流参数(股总静脉、股浅静脉、股深静脉)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、骨碱性磷酸酶(BALP)、骨钙素(BGP)、Ⅰ型胶原羧基端交联肽(CTX-1),比较2组术后下肢静脉血栓发生率、药物不良发生率。结果观察组术前及术后7 d患肢小腿直径差明显低于对照组,NRS评分低于术前及对照组术后7 d,差异均有统计学意义(P<0.05);术后7 d观察组股总静脉、股浅静脉、股深静脉参数、TT、PT、APTT、BALP、BGP水平明显高于术前及对照组术后7天,CTX-1水平明显低于术前及对照组术后7天,差异均有统计学意义(P<0.05);2组不良反应总发生率比较,差异无统计学意义(P>0.05);观察组下肢脉血栓发生率明显低于对照组(P<0.05)。结论丹参片联合那屈肝素钙注射液用于髋部骨折术后,能缓解患者肿胀及疼痛,加快下肢静脉血流,降低患者血液高凝状态,改善骨代谢指标,进而降低血栓发生率。
Objective To investigate the effect of Danshen tablet combined with nadroparin calcium injection on blood flow parameters of lower limb vein after hip fracture surgery.Methods A total of 108 patients who received hip fracture surgery in our hospital from December 2021 to December 2022 were recruited.They were assigned into control group(n=54)and observation group(n=54)according to random number table.Medication was given after surgery.Nadroparin calcium injection was given to all patients,and those in the observation group were additionally managed by Danshen tablet.After 7 days of treatment,the diameteRdifference of affected legs before and 7 days after surgery was compared between the two groups.The Numeric Rating Scale(NRS)score,blood flow parameters of lower limb veins(common femoral vein,superficial femoral vein,deep femoral vein),thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),bone alkaline phosphatase(BALP),osteocalcin(BGP),and C-terminal cross-linked peptide of typeⅠcollagen(CTX-1)were compared before and 7 days after surgery.The incidence of lower limb vein thrombosis and adverse drug reactions were compared between the two groups.Results At 7 days after surgery,the diameteRdifference of affected leg was significantly lower and the NRS score was significantly higher than those before surgery in both groups,which were significantly pronounced in the observation group than those of control group(P<0.05).At 7 days after surgery,the parameters of common femoral vein,superficial femoral vein and deep femoral vein,TT,PT,APTT,BALP and BGP were significantly higher,while CTX-1 level was significantly lower than those before surgery in both groups,which were significantly pronounced in the observation group than those of control group(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).The incidence of lower extremity vein thrombosis in the observation group was significantly lower than that of the control group(P<0.05).Conclusion Danshen tablets combined with nadroparin calcium injection can relieve the swelling and pain of patients after hip fracture surgery,accelerate the venous blood flow of lower limbs,reduce the blood hypercoagulability,improve bone metabolism indicators,and thus reduces the incidence of thrombosis.
作者
王晓亚
杨淑仙
王浩
任猛
李文夺
李金涛
刘建军
刘西斌
任宝
左静
WANG Xiaoya;YANG Shuxian;WANG Hao(Department of Orthopedics,Huanghua Municipal People’s Hospital,Hebei,Huanghua 061100,China)
出处
《河北医药》
CAS
2024年第2期243-246,共4页
Hebei Medical Journal
基金
沧州市科学技术局(编号:213106136)。
关键词
丹参片
那屈肝素钙注射液
髋部骨折术
下肢静脉血流参数
Danshen tablets
nadroparin calcium injection
hip fracture
blood flow parameters of lower limb veins
