摘要
目的探讨血清脂蛋白(a)对不同CISS亚型脑梗死患者的影响。方法选取2018年10月至2022年11月收治的脑梗死患者234例,其中大动脉粥样硬化(LAA)型患者111例、心源性卒中(CS)型患者59例、穿支动脉疾病(PAD)型患者29例、其他病因(OE)型患者13例、不确定病因(UE)型患者22例。收集所有患者的临床资料,检测血清脂蛋白(a)。比较不同CISS亚型脑梗死患者的血清脂蛋白(a)水平,分析不同发病机制的大动脉粥样硬化(LAA)型患者血清脂蛋白(a)水平,并分析大动脉粥样硬化(LAA)型患者的影响因素。结果在234例脑梗死患者中,大动脉粥样硬化(LAA)型患者血清脂蛋白(a)水平显著高于其他类型,且差异有统计学意义(P<0.05)。大动脉粥样硬化(LAA)型患者高血压患病率低于非LAA型患者(P<0.05)。大动脉粥样硬化(LAA)型患者高脂血症患病率高于非大动脉粥样硬化(LAA)型患者(P<0.05)。且大动脉粥样硬化(LAA)型患者多有吸烟史(P<0.05)。高血压、高脂血症、吸烟史均是大动脉粥样硬化(LAA)型患者的影响因素。结论血清脂蛋白(a)在不同CISS亚型脑梗死患者中呈差异表达,大动脉粥样硬化(LAA)型患者的血清脂蛋白(a)表达水平最高。
Objective To investigate the effect of serum lipoprotein(a)[LP(a)]on cerebral infarction patients with different subtypes of the Chinese ischemic stroke subclassification(CISS).Methods A total of 234 cerebral infarction patients were selected in our hospital from October 2018 to November 2022,including 111 patients with large artery atherosclerosis(LAA),59 patients with cardiogenic stroke(CS),29 patients with perforating artery disease(PAD),13 patients with other etiologies(OE),and 22 patients with a uncertain etiology(UE).Clinical data of all patients were collected.Serum LP(a)was detected,which,in cerebral infarction patients with different CISS subtypes was compared.Serum LP(a)in LAA patients with different pathogenic factors was analyzed.The influencing factors for LAA were analyzed.Results Among 234 cerebral infarction patients,serum LP(a)was significantly higher in LAA patients than that of other cerebral infarction patients(P<0.05).The prevalence of hypertension in LAA patients was significantly lower,while that of hyperlipidemia was significantly higher than that of other cerebral infarction patients(both P<0.05).Most LAA patients had a history of smoking(P<0.05).Hypertension,hyperlipidemia and smoking history were influencing factors for LAA.Conclusion Serum LP(a)is differentially expressed in cerebral infarction patients with different CISS subtypes,and among them,LAA patients have the highest serum LP(a).
作者
玄丽慧
杨娜
冯玉婧
王茜
闫丽丽
孟艳宏
李雪梅
XUAN Lihui;YANG Na;FENG Yujing(Department of Neurology,Kailuan General Hospital,Hebei,Tangshan 063000,China)
出处
《河北医药》
CAS
2024年第4期592-594,共3页
Hebei Medical Journal
基金
河北省医学科学研究重点课题计划(编号:20150843)。
关键词
血清脂蛋白(a)
脑梗死
大动脉粥样硬化
serum lipoprotein(a)
cerebral infarction
large artery atherosclerosis
