摘要
二维过渡金属碳/氮化物(MXenes)具有优异的光热转换性能,丰富的表面基团,良好的生物相容性、亲水性和粒径可调性,这使得应用MXenes作为肿瘤诊疗过程中的治疗剂和造影剂具有巨大潜力。本文综述了基于MXenes的肿瘤单一治疗和联合治疗的相关研究,同时介绍了MXenes在肿瘤主动靶向治疗领域的研究,最后阐述了目前MXenes在制备和肿瘤治疗研究中存在的挑战和对未来的展望。
MXenes is an emerging two-dimensional(2D)material,which was composed of layered transition metal carbides and/or nitrides,have attracted enormous attention in the past decade since their innovative discovery by Gogotsi and Barsoum in 2011.The general formula of MXenes is Mn+1XnTx(n=1-4),where M represents transition metal elements(such as Ti,Nb,Ta,etc.),X represents carbon and/or nitrogen,and Tx represents surface terminations(such as—OH,—F,=O,etc.).In recent years,MXenes have been widely applied in the biological field due to their high biocompatibility,abundant surface groups,good conductivity and photothermal properties.Due to the strong absorption of laser in the near infrared region,strong X-ray attenuation ability and surface easily modified by various molecules or nanoparticles,MXenes have been used as photothermal agents and contrast agents in the tumor therapy and tumor diagnosis.This paper reviews the application of MXenes and MXenes-based composites in tumor therapy and active targeting tumor therapy.According to the modal of action on tumor cells,it was divided into monotherapy,bimodal therapy and trimodal therapy.Among them,the monotherapy mainly used the photothermal properties of MXenes for photothermal therapy,studies have found that MXenes QDs can be used for chemodynamic therapy.In addition,sonodynamic therapy can also be achieved by loading the sonosensitizers on the surface of MXenes.Bimodal therapy and trimodal therapy are mainly used to load anticancer drugs,photosensitizers,metal particles and other substances on the surface of MXenes to achieve combination therapy.In contrast to the limited treatment efficacy and possible side effects arising from monotherapy,the development of bimodal therapy and trimodal therapy may harbor the collective merits of respective individual treatments and give rise to much higher anticancer efficacy at lower dosage of therapeutic agents administered,thus avoiding high-dose-induced side effects.The combined use of multiple treatments displayed superior advantages over monotherapy in producing an improved therapy outcome.According to the modal of entry into tumor cells,it was divided into passive targeting and active targeting.Active targeting therapy was mainly divided into homologous targeting therapy and targeting agents targeting therapy.The strategy of homologous targeting therapy was to coat MXenes with tumor cell membrane and increased the uptake of MXenes by tumor cells.Targeting agents targeting therapy used targeting agents to specifically bind to the receptors on the surface of tumor cells,subsequently,the precise uptake of MXenes by tumor cells was achieved.Finally,the current challenges and future development trends of MXenes in preparation technology and tumor therapy are discussed.
作者
刘美青
赵璐
白云峰
冯锋
LIU Mei-Qing;ZHAO Lu;BAI Yun-Feng;FENG Feng(College of Chemistry and Chemical Engineering,Shanxi Provincial Key Laboratory of Chemical Biosensing,Shanxi Datong University,Datong 037009,China;College of Energy Chemistry and Materials Engineering,Shanxi Institute of Energy,Taiyuan 030600,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
2024年第2期328-344,共17页
Progress In Biochemistry and Biophysics
基金
山西省高等学校科学研究优秀成果培育项目(2020KJ023)
山西省省筹资金资助回国留学人员科研项目(2020-133)
山西省高等学校科技创新项目(2021L368,2022L424)
山西省基础研究计划(202303021211324)
山西大同大学研究生教育创新项目(22CX13)资助。
