摘要
目的观察消瘿散结方联合左甲状腺素钠片对结节性甲状腺肿患者甲状腺功能和结节大小的影响。方法选取2021年7月—2022年7月山西省人民医院中医科收治的100例符合纳入和排除标准的结节性甲状腺肿患者,采用随机数字表法将上述患者均分为两组,其中常规治疗组50例,予以甲状腺素钠片治疗,消瘿散结组50例,在常规治疗组基础上给予消瘿散结方治疗。比较两组患者的临床疗效、甲状腺结节大小和数量变化,以及干预前后的心理状态及不良反应情况。结果常规治疗组的总有效率为80.00%(40/50),消瘿散结组的总有效率为94.00%(47/50),与常规治疗组比较,消瘿散结组的总有效率明显升高(P<0.05)。两组患者干预完成后,消瘿散结组患者的结节大小、数量以及动脉血流参数水平相较于常规治疗组均明显下降(P<0.01)。与常规治疗组比较,消瘿散结组病人的游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)以及促甲状腺激素(TSH)水平在干预前后均无明显变化(P>0.05)。干预前两组患者的焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分差异无统计学意义(P>0.05)。干预完成后,消瘿散结组病人的SAS评分、SDS评分水平相较于常规治疗组明显降低(P<0.01)。治疗过程中,两组患者主要不良反应有头痛、心悸、药疹以及恶心呕吐等,常规治疗组的总发生率为18.00%(9/50),消瘿散结组的总发生率为14.00%(7/50),与常规治疗组比较,消瘿散结组的不良反应总发生率差异无统计学意义(P>0.05)。结论左甲状腺素钠片联合消瘿散结方能够提高结节性甲状腺肿(气郁痰凝型)的临床疗效,改善甲状腺功能,减少结节数量、缩小结节体积,其疗效优于单纯左甲状腺素钠治疗,适宜临床推广。
Objective To observe the effect of Xiaoying Sanjie Decoction(消瘿散结方)combined with levothyroxine sodium tablets on thyroid function and nodular size in patients with nodular goiter.Methods A total of 100 patients with nodular goiter admitted to the Department of Traditional Chinese Medicine,Shanxi Provincial People's Hospital from July 2021 to July 2022 who met the inclusion and exclusion criteria were selected and divided into two groups by random number table method.Fifty cases in the conventional treatment group were given the levothyroxine sodium tablets and 50 cases in the Xiaoying Sanjie Decoction group were given Xiaoying Sanjie Decoction on the basis of the conventional treatment group.The clinical efficacy,size and number of thyroid nodules,psychological state and adverse reactions before and after intervention were compared between the two groups.Results The total effective rate of the conventional treatment group was 80.00%(40/50)and that of the Xiaoying Sanjie Decoction group was 94.00%(47/50).The total effective rate of the Xiaoying Sanjie Decoction group was significantly increased(P<0.05).After the completion of the intervention,the size and number of nodules and arterial blood flow parameters of the patients in the Xiaoying Sanjie Decoction group were significantly decreased compared with those in the conventional treatment group(P<0.01).Compared with those of the conventional treatment group,there were no significant changes in the levels of,free triiodothyronine(FT3),free thyroxine(FT4)or thyroid hormone(TSH)before and after the intervention in the Xiaoying Sanjie Decoction group(P>0.05).Before intervention,there was no significant difference in Self Rating Anxiety Scale(SAS)or Self Rating Depression Scale(SDS)score between the two groups(P>0.05).After the completion of intervention,the SAS score and SDS score of the patients in the Xiaoying Sanjie Decoction group were significantly lower than those in the conventional treatment group(P<0.01).During the treatment,the main adverse reactions of the two groups were headache,palpitation,drug eruption,nausea and vomiting,etc.The total adverse reaction incidence of the conventional treatment group was 18.00%(9/50)and the that of the Xiaoying Sanjie Decoction group was 14.00%(7/50).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of levothyroxine sodium tablets and Xiaoying Sanjie Decoction can improve the clinical efficacy of nodular goiter(Qi stagnation and phlegm coagulation type),improve thyroid function,reduce the number of nodules and reduce the volume of nodules.Its efficacy is superior to that of simple levothyroxine sodium treatment,and is suitable for clinical promotion.
作者
颉慧敏
张永康
冯浩丽
王旭
JIE Huimin;ZHANG Yongkang;FENG Haoli;WANG Xu(Shanxi Provincial People's Hospital,Taiyuan 030012,Shanxi,China;Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第1期70-73,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局“十二五”重点专科培育项目([2012]2-2-209)
山西省中医药管理局项目(2020ZYYC045)。
关键词
消瘿散结方
左甲状腺素钠片
结节性甲状腺肿
甲状腺功能
结节大小
Xiaoying Sanjie Decoction(消瘿散结方)
levothyroxine sodium tablets
nodular goiter
thyroid function
nodule size
