摘要
目的探讨祛瘀通络方联合灌汤1号对盆腔炎性疾病后遗症患者炎症因子的影响。方法选取100例盆腔炎性疾病后遗症患者,随机分为对照组与治疗组,每组50例,对照组采用桂枝茯苓丸口服治疗,治疗组采用祛瘀通络方口服联合灌汤1号保留灌肠治疗,疗程3个月。观察中医证候积分、局部症状及血清白细胞介素-8(Interleukin-8,IL-8)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子(Tumor necrosis factor-α,TNF-α)变化。结果两组患者治疗前中医证候积分比较差异无统计学意义(P>0.05),治疗后中医证候积分较治疗前下降,治疗组下降程度明显大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前局部症状评分比较差异无统计学意义(P>0.05),治疗后局部症状的评分较治疗前下降,治疗组下降程度明显大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前血清IL-8、IL-6、TNF-α比较差异无统计学意义(P>0.05),治疗后IL-8、IL-6、TNF-α水平较治疗前下降,治疗组下降程度明显大于对照组,比较差异有统计学意义(P<0.05);治疗组治疗疗效明显优于对照组(P<0.05),治疗组治疗总有效率为96.00%(48/50),高于对照组80.00%(40/50),比较差异有统计学意义(P<0.05)。结论盆腔炎性疾病后遗症患者采用祛瘀通络方联合灌汤1号治疗,可改善自觉症状及妇科阳性体征,降低血清促炎因子水平,提高治疗疗效。
Objective To discuss the effect of Quyu Tongluo Prescription(祛瘀通络方)combined with Enema No.1 on inflammatory factors in patients with sequelae of pelvic inflammatory disease(SPID).Methods It collected 100 cases of patients with sequelae of SPID and they were divided into the control group and observation group,50 cases in each group.The control group was treated with Guizhi Fuling Pill(桂枝茯苓丸).The observation group was treated Quyu Tongluo Prescription combined with Enema No.1.The treatment course lasted for 3 months.TCM syndrome scores,local symptoms,serum interleukin-8(IL-8),interleukin-6(IL-6)and tumor necrosis factor(TNF-α)were observed.Results There was no significant difference in TCM syndrome scores between the two groups before treatment(P>0.05).The TCM syndrome scores decreased after treatment(P<0.05),and the decrease degree in the observation group was significantly greater than that in the control group(P<0.05).There was no significant difference in local symptom score before treatment between the two groups(P>0.05),and the decrease degree in the observation group was significantly greater than that in the control group(P<0.05).There were no significant differences in serum IL-8,IL-6 or TNF-α between the two groups before treatment(P>0.05).The levels of IL-8,IL-6 and TNF-α decreased after treatment(P<0.05),and the decrease degree of the observation group was significantly greater than that of the control group(P<0.05).The therapeutic effect of the observation group was significantly better than that of the control group(P<0.05),and the total effective rate of the observation group was 96.00%(48/50),and that of the control group was 80.00%(40/50).The difference was statistically significant(P<0.05).Conclusion Quyu Tongluo Prescription combined with Enema No.1 can improve the conscious symptoms and positive signs of patients with sequelae of PSID,reduce the levels of serum proinflammatory factors and improve the therapeutic effect.
作者
王冰玉
黄巧玲
傅金英
刘青
WANG Bingyu;HUANG Qiaoling;FU Jinying;LIU Qing(Henan Hospital of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China;Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China;Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450004,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第2期224-227,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河南省中医药科学研究专项(2022ZY1082)。
关键词
祛瘀通络方
灌汤1号
盆腔炎性疾病后遗症
炎症因子
Quyu Tongluo Prescription(祛瘀通络方)
Enema No.1
sequelae of pelvic inflammatory disease
inflammatory factors
