摘要
目的研究血府逐瘀汤治疗股骨头缺血性坏死的疗效及患者凝血功能、血清学指标变化。方法选取2020年1月-2022年9月黑龙江中医药大学附属第二医院收治的126例股骨头缺血性坏死患者为研究对象,按简单随机分组法分为手术组和中药组,各63例。所有患者均进行手术治疗,术后进行常规干预,在此基础上,中药组采用血府逐瘀汤治疗,2组均治疗3个月。统计2组治疗3个月后的疗效,比较2组治疗前和治疗3个月后中医症状积分、血清学指标、凝血功能及康复情况。结果治疗3个月后,中药组治疗总有效例数为61例,总有效率为96.83%,手术组治疗总有效例数为55例,总有效率为87.30%,中药组总有效率高于手术组(P<0.05)。治疗3个月后与治疗前比较,2组疼痛、肿胀、便秘、口渴、视觉模拟评分(VAS)、外周血纤维蛋白原(FIB)水平降低,手术组高于中药组(P<0.05)。2组血清胰岛素样生长因子1(IGF-1)、转化生长因子-β1(TGF-β1)、骨形态发生蛋白(BMP-2)、血管内皮生长因子(VEGF)水平及髋关节功能评分、骨密度升高,手术组低于中药组(P<0.05)。治疗3个月后与治疗前比较,2组凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)延长,中药组长于手术组(P<0.05)。结论血府逐瘀汤可改善股骨头缺血性坏死患者中医症状、凝血功能及血清学指标,提高患者髋关节功能及增加骨密度,降低疼痛,疗效较好。
Objective To study the therapeutic effect of Xuefu Zhuyu Decoction on ischemic necrosis of the femoral head and the changes of coagulation function and serological indexes.Methods From January 2020 to September 2022,126 patients with ischemic necrosis of the femoral head admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine were as the research subjects and randomly divided into the operation group(63 cases)and the Chinese medicine group(63 cases).All patients underwent surgical treatment and routine intervention after surgery.On the basis of this treatment,the Chinese medicine group was treated with Xuefu Zhuyu Decoction,and both groups were treated for 3 months.The therapeutic effects of two groups after 3 months of treatment were statistically analyzed.And the scores of traditional Chinese medicine symptoms,serological indexes levels,coagulation function and rehabilitation were compared between two groups before treatment and after 3 months of treatment.Results After 3 months of treatment,in the Chinese medicine group,the total effective cases were 61cases,and the total effective rate was 96.83%;And in the operation group,the total effective cases were 55 cases,and the total effective rate was 87.30%.The total effective rate of the Chinese medicine group was higher than that of the operation group(P<0.05).After 3 months of treatment,compared with before treatment,pain,swelling,constipation,thirst,visual analogue scale(VAS)and peripheral blood fibrinogen(FIB)levels in two groups decreased,and the Chinese medicine group was lower than the operation group(P<0.05).Serum levels of insulin-like growth factor 1(IGF-1),transforming growth factor-β1(TGF-β1),bone morphogenetic protein 2(BMP-2)and vascular endothelial growth factor(VEGF),and hip joint function score and bone density increased in both groups,and the Chinese medicine group was higher than the operation group(P<0.05).After 3 months of treatment,compared with before treatment,the prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)in two groups were prolonged,and the Chinese medicine group was longer than the operation group(P<0.05).Conclusion Xuefu Zhuyu Decoction can improve the symptoms of traditional Chinese medicine,coagulation function and serum indexes levels in patients with ischemic necrosis of the femoral head,improve the hip joint function and bone density of patients,and reduce pain.The treatment method has the good therapeutic effect.
作者
刘泽霖
任天琦
高鲁
胡海
LIU Zelin;REN Tianqi;GAO Lu;HU Hai(Outpatient Department,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China;Department of Orthopaedics and Traumatology,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)
出处
《长春中医药大学学报》
2024年第3期286-290,共5页
Journal of Changchun University of Chinese Medicine
基金
黑龙江省2022年度中医药科研计划项目(ZYW2022-027)。
关键词
股骨头缺血性坏死
血府逐瘀汤
凝血功能
血清学指标
ischemic necrosis of the femoral head
Xuefu Zhuyu Decoction
coagulation function
serological index
