摘要
目的探讨银杏达莫注射液联合琥珀酸美托洛尔对冠心病心绞痛患者水平的影响。方法选取济南市第四人民医院2019年7月-2021年7月收治的冠心病心绞痛患者80例,随机数字表法将其分为对照组(38例)和观察组(42例)。对照组采用银杏达莫注射液治疗;观察组在对照组基础上给予琥珀酸美托洛尔治疗。比较2组治疗前后心绞痛发作次数与持续时间、血清炎症因子水平、24 h动态血压、心率变异性(heart rate variabiliby,HRV)、血液流变学指标;比较治疗后2组临床治疗效果、不良反应。结果治疗后,观察组心绞痛发作次数、持续时间、6 min步行测试距离与对照组相比较,发作次数持续较短、距离较长(P<0.05);治疗后,2组血清肿瘤坏死因子α(TNF-α)、细胞间黏附分子-1(ICAM-1)、C-反应蛋白(CRP)水平相比均低于治疗前,HRV比较均高于治疗前,且观察组明显优于对照组(P<0.05);治疗后,2组的24 h动态血压、纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度差值相比均低于治疗前,且观察组均低于对照组,差异具有统计学意义(P<0.05)。结论经琥珀酸美托洛尔联合银杏达莫注射液对早期冠心病心绞痛患者进行治疗后,降低患者血黏度,减少患者的发作次数与持续时间,HRV均升高,血液流变学指标、24 h动态血压水平均降低,血清炎症因子得到抑制,防止病情进一步的发展,临床效果较为显著。
Objective To explore the effect of Ginkgo Leaf Extract and Dipyridamole Injection combined with Metoprolol succinate on angina pectoris of coronary heart disease.Methods 80 patients with angina pectoris of coronary heart disease admitted to Jinan Fourth People's Hospital from July 2019 to July 2021 were selected and divided into the control group(38 cases)and the observation group(42 cases)acording to random number table method.The control group was treated with Ginkgo Leaf Extract and Dipyridamole Injection,and the observation group was treated with Metoprolol succinate on the basis of the treatment of the control group.The frequency and duration of angina attacks,the levels of serum inflammatory factors,24-hour ambulatory blood pressure,heart rate variability(HRV)and hemorheological parameters were compared between two groups before and after treatment.The clinical effects and adverse reactions of two groups were compared after treatment.Results After treatment,in the observation group the frequency and duration of angina attacks were lower and shorter than those in the control group,and 6 minute walking test distance was longer than that in the control Group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),intercellular cell adhesion molecule(ICAM-1)and C-reactive protein(CRP)in two groups were lower than those before treatment,and the heart rate variability(HRV)was higher than that before treatment,and the observation group was significantly better than the control group(P<0.05).After treatment,the difference of 24-hour ambulatory blood pressure,fibrinogen,plasma viscosity,whole blood low shear viscosity and whole blood high shear viscosity in two groups was lower than those before treatment,and the observation group was lower than the control group,and there was statistically significant difference(P<0.05).Conclusion After the treatment with Metoprolol succinate combined with Ginkgo Leaf Extract and Dipyridamole Injection for patients with angina pectoris of early coronary heart disease,the blood viscosity of patients is reduced,the frequency and duration of angina attacks of patients are reduced,HRV is increased,hemorheology indexes levels and 24-hour ambulatory blood pressure are decreased,serum inflammatory factors are inhibited,which can prevent further development of the disease.This therapy has the significant clinical effect.
作者
王婧
侯远
朱祚云
WANG Jing;HOU Yuan;ZHU Zuoyun(Jinan Fourth People's Hospital,Jinan 250031,China)
出处
《长春中医药大学学报》
2024年第3期315-319,共5页
Journal of Changchun University of Chinese Medicine
基金
山东省医药卫生科技发展计划项目(20210012796)。
关键词
银杏达莫注射液
冠心病
心绞痛
琥珀酸美托洛尔
血液流变学
心率变异性
Ginkgo Leaf Extract and Dipyridamole Injection
coronary heart disease
angina pectoris
Metoprolol succinate
hemorheology
heart rate variability
