摘要
背景抑郁障碍患者的主观认知功能与客观认知功能存在差异。目前,关于主客观认知功能差异影响因素的研究有限。目的探索抑郁障碍患者主观和客观认知功能的差异及其影响因素,为进一步理解抑郁障碍患者认知功能受损情况提供参考。方法纳入2022年1月13日—2023年12月11日在成都市第四人民医院门诊就诊或住院治疗的、符合《精神障碍诊断与统计手册(第5版)》(DSM-5)抑郁障碍诊断标准的77例患者为研究对象。采用蒙哥马利-艾森贝格抑郁量表(MADRS)评定患者抑郁症状严重程度,采用抑郁感知缺陷问卷(PDQ-D)和中国简版神经认知成套测验(C-BCT)分别评定患者的主观认知功能和客观认知功能,采用席汉残疾量表(SDS)评定患者的社会功能,以临床总体印象量表-疾病严重程度量表(CGI-SI)评定患者病情严重程度。采用Pearson相关分析考查年龄、受教育年限、MADRS总评分、SDS总评分、CGI-SI评分与主客观认知功能及其差异的相关性。采用多元线性回归探索主客观认知功能差异的影响因素。结果是否用药的抑郁障碍患者PDQ-D总评分和主客观认知功能差异(D值)比较差异均有统计学意义(t=-4.228、-2.392,P<0.05或0.01)。抑郁障碍患者主观认知功能与客观认知功能的相关性无统计学意义(r=-0.148,P>0.05);年龄和受教育年限与PDQ-D总评分均呈负相关(r=-0.333、-0.369,P均<0.01),MADRS总评分、SDS总评分以及CGI-SI评分与PDQ-D总评分均呈正相关(r=0.487、0.637、0.434,P均<0.01);年龄、受教育年限与D值均呈负相关(r=-0.411、-0.362,P均<0.01),MADRS总评分、SDS总评分、CGI-SI评分与D值均呈正相关(r=0.259、0.468、0.299,P<0.05或0.01)。年龄(β=-0.328,P<0.01)和SDS总评分(β=0.409,P<0.01)是D值的预测因子。结论抑郁障碍患者主观认知功能与客观认知功能的差异可能与年龄、受教育年限、症状严重程度以及社会功能受损相关。
Background There exist differences in the subjective and objective cognitive functions of patients with depressive disorder,ane there are limited research on influencing factors of such phenomenon currently.Objective To explore the differences in subjective and objective cognitive function in patients with depressive disorder as well as influencing factors,and to provide references for further understanding of cognitive impairment in patients with depressive disorder.Methods A total of 77 patients with depressive disorder who received outpatient or inpatient treatment in the Fourth People's Hospital of Chengdu from January 13,2022 to December 11,2023 were selected for the study.These patients also met the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders,fifth edition(DSM-5).Various tools were employed to assess patients in this study:Montgomery-Asberg Depression Rating Scale(MADRS)for the depressive symptoms,Perceived Deficits Questionnaire for Depression(PDQ-D)and Chinese Version of Brief Neurocognitive Test Battery(C-BCT)for the subjective and objective cognitive function,Sheehan Disability Scale(SDS)for the social function,and Clinical Global Impression-Severity of Illness(CGI-SI)for the severity of patient's condition.Pearson correlation analysis was used to examine the correlation of subjective and objective cognitive function and their differences with age,years of education,MADRS total score,SDS total score,and CGI-SI score.Multiple linear regression was used to explore the influencing factors of the differences between subjective and objective cognitive function.Results There was a statistically significant difference in the total PDQ-D scores and the difference of subjective and objective cognitive function(D value)between depressive patients with and without medication(t=-4.228,-2.392,P<0.05 or 0.01).There was no statistically significant correlation in subjective and objective cognitive function in patients with depressive disorder(r=-0.148,P>0.05).Negative correlations can be observed between the PDQ-D total score and age or years of education(r=-0.333,-0.369,P<0.01).The PDQ-D total score was positively correlated with MADRS total score,SDS total score and CGI-SI score(r=0.487,0.637,0.434,P<0.01).D value was negatively correlated with age and years of education(r=-0.411,-0.362,P<0.01),while positively correlated with MADRS total score,SDS total score and CGI-SI score(r=0.259,0.468,0.299,P<0.05 or 0.01).Age(β=-0.328,P<0.01)and SDS total score(β=0.409,P<0.01)were two predictive factors for D value.Conclusion The difference between subjective and objective cognitive function among patients with depressive disorder is related to several factors including age,years of education,severity of symptoms and impairment of social function.
作者
傅琳娜
王敏
杨潇
窦翊愷
韦锦学
何宗岭
于跃
蔡晓
马小红
Fu Linna;Wang Min;Yang Xiao;Dou Yikai;Wei Jinxue;He Zongling;Yu Yue;Cai Xiao;Ma Xiaohong(West China Hospital,Sichuan University,Chengdu 610041,China;The Fourth People's Hospital of Chengdu,Chengdu 610036,China)
出处
《四川精神卫生》
2024年第1期26-32,共7页
Sichuan Mental Health
基金
国家自然科学基金面上项目(项目名称:解释偏向介导抑郁症自杀意念的神经机制研究,项目编号:62173069)
科技创新2030-“脑科学与类脑研究”重大项目(项目名称:抑郁症的发病机制及干预技术研究,项目编号:2022ZD0211700)
成都市科技局重点研发支持计划重大应用示范项目(项目名称:基于数字疗法的青少年抑郁症远程心理干预系统开发与推广应用,项目编号:2022-YF09-00023-SN)。
关键词
抑郁障碍
主观认知功能
客观认知功能
差异
Depressive disorder
Subjective cognition function
Objective cognition function
Difference
