摘要
血吸虫病是一种严重危害人畜健康和社会经济发展的人兽共患寄生虫病。宿主感染日本血吸虫后,沉积于肝脏的虫卵分泌可溶性虫卵抗原(SEA)主要刺激肝星状细胞(HSC)产生免疫应答反应,导致细胞外基质(ECM)过度沉积,最终引起肝纤维化,造成宿主严重的病理损害。对于血吸虫病晚期患者,即使进行了彻底的杀虫治疗,肝纤维化仍会发展、恶化,而目前尚无有效针对肝纤维化的治疗策略,因此进行肝纤维化的机制研究将对血吸虫病的防治起到积极作用。本文从日本血吸虫病肝纤维化的形成与调节、日本血吸虫病肝纤维化的诊断与治疗等方面进行综述。
Schistosomiasis is a parasitic zoonoses that seriously threatens human health and economic development.After the host is infected with Schistosomajaponicum,the soluble egg antigen(SEA)produced by eggs in the liver stimulate an immune response of the hepatic stellate cells(HSC),resulting in excessive deposition of extracellular matrix(ECM)and eventually leading to liverfibrosis.For advanced stage of schistosomiasis,liverfibrosis will continue to develop and deteriorate though insecticidal treatment is performed.However,there is no effective treatment strategy for liverfibrosis at present.Therefore,studies on the mechanism of liverfibrosis will also contribute to the prevention and control of schistosomiasis.In this article,we review the formation,regulation,diagnosis and treatment of liverfibrosis induced byS.japonicum.
作者
钟昊然
金亚美
ZHONG Haoran;JIN Yamei(National Reference Laboratory for Animal Schistosomiasis,Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affair,Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China)
出处
《中国动物传染病学报》
CAS
北大核心
2023年第6期177-183,共7页
Chinese Journal of Animal Infectious Diseases
基金
上海市自然科学基金(20ZR1469300)
国家自然科学基金(31672245)
中国农业科学院科技创新工程。
关键词
日本血吸虫
肝纤维化
发病机制
信号通路
诊断与治疗
Schistosomajaponicum
liverfibrosis
pathogenesis
signaling pathway
diagnosis and treatment
