摘要
目的:炎症在大动脉炎(Takayasu arteritis,TA)患者情绪障碍中的作用尚不明确,本研究旨在探索TA患者发生情绪障碍的炎症相关危险因素。方法:研究共纳入2021年1月至2021年12月,在北京安贞医院风湿免疫科明确诊断为TA的59例患者,根据是否存在情绪障碍分为两组:情绪障碍组(n=31)和无情绪障碍组(n=28)。通过单因素以及多因素Logistic回归分析确定各炎症因子与TA患者情绪障碍之间的关系。通过局部加权回归(Lowess)对多因素回归分析中有统计学意义的炎症因子绘制符合总趋势的曲线。结果:情绪障碍组TA患者WBC(P<0.001),中性粒细胞(P=0.021)、红细胞沉降率(P=0.029)、IL-6 (P<0.001)、IL-10 (P=0.024)及TNF-α(P<0.001)、干扰素γ(P=0.003)均显著升高。在多因素Logistic模型中,调整混杂因素后,IL-6(OR=1.24,95%CI:1.02~1.50,P=0.030)、IL-10(OR=3.12,95%CI:1.28~6.37,P=0.025)及TNF-α(OR=1.94,95%CI:1.03~3.66,P=0.040)和TA患者情绪障碍发生风险相关。Lowess曲线结果同Logistic回归分析一致:患者情绪障碍发生风险分别随着IL-6、IL-10、及TNF-α的升高而显著升高。结论:TA患者情绪障碍与炎症密切相关,IL-6、IL-10及TNF-α是其危险因素。
Objective:The role of inflammation in mood disorders in patients with Takayasu arteritis(TA)is unclear.The purpose of this study was to explore the association between inflammation-related risk factors and mood disorders in TA patients.Methods:A total of 59 patients diagnosed with TA in the Department of Rheumatology and Immunology at Beijing Anzhen Hospital between January 2021 and December 2021 were included in this study.Enrolled patients were divided into two groups according to whether they had mood disorders:mood disorder group(n=31)and mood disorder-free group(n=28).Univariate and multivariate Logistic regression analysis was used to determine the relationship between various inflammatory factors and mood disorders in TA patients.The association between statistically significant inflammatory factors and mood disorders were plotted according to the locally weighted scatterplot smoothing(Lowess).Results:White blood cell (P<0.001), neutrophil (P=0.021), erythrocyte sedimentation rate (P=0.029), IL- (P<0.001), IL-10(P=0.024) and TNF-α (P<0.001) and interferon-γ (P=0.003) significantly increased in TA patients with mooddisorder. In the multivariate model, after adjusting for confounding factors, IL-6 (OR=1.24, 95%CI:1.02-1.50,P=0.030), IL-10 (OR=3.12, 95%CI:1.28-6.37, P=0.025) and TNF-α(OR=1.94, 95%CI:1.03-3.66, P=0.040)were independently associated with the increased risk of mood disorders in TA patients. The results ofLowess curves were consistent with Logistic regression analysis: the incidence of mood disorders increasedsignificantly with the increase of IL-6, IL-10 and TNF-α, respectively. Conclusions: The mood disorders of TApatients were closely related to inflammation. IL-6, IL-10 and TNF-α were independent risk factors.
作者
唐雪
杜娟
曹冬梅
郭萌
张雅昕
潘丽丽
张喜维
TANG Xue;DU Juan;CAO Dongmei;GUO Meng;ZHANG Yaxin;PAN Lili;ZHANG Xiwei(Department of Rheumatism and Immunology,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)
出处
《心肺血管病杂志》
CAS
2024年第2期158-163,共6页
Journal of Cardiovascular and Pulmonary Diseases
基金
国家自然科学基金面上项目(82270427)。
关键词
大动脉炎
情绪障碍
焦虑
抑郁
炎症
Takayasu arteritis
Mood disorder
Inflammation
Anxiety
Depression
