摘要
目的探讨不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症(以下简称甲减)的疗效及对血压的影响。方法抽取2021年2月至2022年2月晋城市人民医院收治的老年亚临床甲减患者66例,根据双色球法分为对照组与观察组,每组33例。对照组患者予以小剂量左甲状腺素治疗,观察组患者予以大剂量左甲状腺素治疗。比较两组临床疗效,比较两组治疗前后血压情况、甲状腺功能指标[促甲状腺素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)],比较两组不良反应发生率。结果观察组总有效率(96.97%,32/33)高于对照组(78.79%,26/33),P<0.05。治疗前,两组收缩压、舒张压、甲状腺功能指标比较差异未见统计学意义(P>0.05);治疗后,观察组收缩压、舒张压均低于对照组,观察组TSH水平低于对照组,FT3、FT4水平高于对照组(P均<0.05);观察组不良反应发生率(15.15%,5/33)与对照组(12.12%,4/33)比较差异未见统计学意义(P>0.05)。结论与小剂量左甲状腺素比较,大剂量左甲状腺素治疗老年亚临床甲减的疗效更好,可以更好地改善患者血压、甲状腺功能,且安全性好。
Objective To investigate the efficacy of different doses of levothyroxine in the treatment of subclinical hypothyroidism in the elderly,and its impact on blood pressure.Methods A total of 66 elderly subclinical hypothyroidism patients admitted to Jincheng People’s Hospital from February 2021 to February 2022 were selected,and they were divided into control group and observation group according to dichromatic sphere method,with 33 cases in each group.The control group was treated with low-dose levothyroxine,while the observation group was treated with high-dose levothyroxine.The clinical efficacy of the two groups were compared.The blood pressure,thyroid function indicators,including thyroid stimulating hormone(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)were compared between the two groups before and after treatment.The incidence of adverse reactions of the two groups were compared.Results The total effective rate of the observation group(96.97%,32/33)was higher than that of the control group(78.79%,26/33),P<0.05.Before treatment,there were no statistically significant difference in systolic blood pressure,diastolic blood pressure,thyroid function indicators between the two groups(P>0.05).After treatment,the systolic and diastolic blood pressure in the observation group were lower than those in the control group;the TSH level in the observation group was lower than that in the control group;while the levels of FT3 and FT4 in the observation group were higher than those in the control group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group(15.15%,5/33)and the control group(12.12%,4/33),P>0.05.Conclusions Compared with low-dose levothyroxine,high-dose levothyroxine has a better therapeutic effect on elderly subclinical hypothyroidism,which can better improve patients’blood pressure,thyroid function,with good safety.
作者
延樱
Yan Ying(Department of Endocrinology,Jincheng People’s Hospital,Jincheng 048000,China)
出处
《中国实用医刊》
2023年第22期96-99,共4页
Chinese Journal of Practical Medicine
