摘要
目的 探讨自报职业性噪声暴露与成人哮喘患者血浆中炎性细胞因子表达水平的关联性。方法 以910例成人哮喘患者为研究对象,收集患者的职业性噪声暴露接触史等信息,检测其血浆中可溶性白细胞分化抗原14(sCD14)、补体因子D(CFD)、嗜酸性粒细胞趋化因子11(CCL11)和IL-9的表达水平。采用多元线性回归模型分析自报职业性噪声暴露与患者血浆中四种因子表达水平的关联,并分析与各混杂因素之间的交互作用。结果 自报有职业性噪声暴露的成人哮喘患者血浆中CCL11、sCD14和CFD的表达水平显著高于无职业性噪声暴露史的患者(P<0.05)。调整混杂因素后,与自报无职业性噪声暴露史的患者相比,自报有职业性噪声暴露史的患者血浆中CFD的表达增加0.17 (95%CI:0.02~0.31)个自然对数单位;当处于缓解期时,自报有职业性噪声暴露的患者血浆中CCL11和sCD14的表达分别增加0.27 (95%CI:0.05~0.49)和0.22 (95%CI:0.02~0.41)个自然对数单位。交互作用分析显示,自报职业性噪声暴露史与吸烟、养宠物分别对CCL11和CFD的表达水平均具有显著相乘交互作用(P<0.05)。结论 自报职业性噪声暴露与成人哮喘患者血浆中CFD、CCL11及sCD14的表达水平显著增加有关。
Objectives To investigate the relationship between self-reported occupational noise exposure and levels of plasma inflammatory cytokines in asthmatic patients.Methods A total of 910 adult asthmatic patients were selected as the study subjects,and their occupational noise exposure history and other related information were collected.The peripheral blood samples were collected from the patients,and the expression levels of plasma soluble CD14(sCD14),complement factor D(CFD),Eotaxin-11(CCL11),and IL-9 were determined.The relationship between self-reported occupational noise exposure and the expression levels of the four inflammatory cytokines in patients′plasma were analyzed using multiple linear regression models.The interactions between confounding factors and self-reported occupational noise exposure were further analyzed by interaction analysis.Results The plasma CCL11,sCD14 and CFD expressions in asthmatic patients with self-reported occupational noise exposure were significantly higher than those in patients without the exposure(P<0.05).After adjusting for confounding factors,compared with patients reporting no occupational noise exposure,the plasma CFD expression was increased by 0.17(95%CI:0.02~0.31)natural logarithm units in patients with self-reported occupational noise exposure.During remission,the levels of plasma CCL11 and sCD14 in asthmatic patients with self-reported occupational noise exposure were increased by 0.27(95%CI:0.05~0.49)and 0.22(95%CI:0.02~0.41)natural logarithm units,respectively,when compared with patients without the exposure.Interaction analysis showed that self-reported occupational noise exposure had significant multiplicative interaction with smoking or pet ownership on plasma CCL11 or CFD expressions in asthmatic patients(all P<0.05).Conclusion Self-reported occupational noise exposure is significantly associated with increased expression levels of plasma CFD,CCL11,and sCD14 in adult asthmatic patients.
作者
汪洋
李连凤
石玉琴
张玲
王冬明
陈卫红
周婷
WANG Yang;LI Lianfeng;SHI Yuqin;ZHANG Ling;WANG Dongming;CHEN Weihong;ZHOU Ting(School of Public Health,Wuhan University of Science and Technology,Wuhan,Hubei 430065,China;Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Wuhan University of Science and Technology,Wuhan,Hubei 430065,China;School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)
出处
《公共卫生与预防医学》
2024年第2期96-100,共5页
Journal of Public Health and Preventive Medicine
基金
湖北省教育厅科学研究计划指导性项目(B2020016)。
