摘要
目的分析肇庆市先天性甲状腺功能减退症(CH)患儿碘营养水平现况,为该地区CH患儿科学补碘提供依据。方法选取2021年4月至2022年8月在肇庆本辖区内运用新生儿疾病筛查技术筛查确诊并规律跟踪治疗的180例CH患儿作为研究对象,通过尿碘的砷铈催化分光光度法测定,对CH患儿的碘营养水平进行分析。结果180例CH患儿的平均尿碘水平为(198.35±40.25)μg/L,其中碘营养不足2例(1.11%),碘营养适宜123例(68.33%),碘营养超过适宜量40例(22.22%),碘营养超标者15例(8.33%)。不同年龄和性别的尿碘和碘营养状态分布比较,差异无统计学意义(P>0.05);不同营养状态下的FT3、FT4、TT3、TT4、TSH水平比较,差异有统计学意义(P<0.05);CH患儿的尿碘水平与FT3、FT4、TT3及TT4呈负相关(P<0.05),与TSH无相关性(P>0.05)。结论肇庆市先天性甲状腺功能减退症患儿碘营养水平相对合理,临床在接收此类患儿的同时还需兼顾预防碘营养缺乏,以促进患儿更好地生长发育。
Objective To analyze the iodine nutritional status of children with congenital hypothyroidism(CH)in Zhaoqing City,and to provide a basis for scientific iodine supplementation for CH children in this area.Methods A total of 180 children with CH who were diagnosed by newborn disease screening technology and regularly followed up and treated in Zhaoqing City from April 2021 to August 2022 were selected as the research objects.Urinary iodine was determined by arsenic cerium catalytic spectrophotometry,and the iodine nutritional level of children with CH was analyzed.Results The average urinary iodine level of 180 children with CH was(198.35±40.25)μg/L,of which 2 cases(1.11%)had insufficient iodine nutrition,123 cases(68.33%)had adequate iodine nutrition,40 cases(22.22%)had iodine nutrition above the appropriate amount,and 15 cases(8.33%)had iodine nutrition above the standard.There were no significant differences in the distribution of urinary iodine and iodine nutritional status between different ages and genders(P>0.05).There were significant differences in the levels of FT3,FT4,TT3,TT4 and TSH in different nutritional status(P<0.05).In children with CH,the urinary iodine level was negatively correlated with FT3,FT4,TT3 and TT4(P<0.05),but not with TSH(P>0.05).Conclusion The iodine nutrition level of children with congenital hypothyroidism in Zhaoqing City is relatively reasonable.It is necessary to take into account the prevention of iodine deficiency while accepting such children in order to promote the better growth and development of children.
作者
黄锶
陈丽华
郑宏基
HUANG Si;CHEN Lihua;ZHENG Hongji(Department of Child Health Care,Zhaoqing Maternal and Child Health Hospital,Guangdong Province,Zhaoqing526060,China)
出处
《中国当代医药》
CAS
2024年第6期62-65,共4页
China Modern Medicine
基金
广东省肇庆市科技计划项目(2021040310014)。
