摘要
目的探讨消渴肾宝丸联合热敏灸治疗气阴两虚、瘀血内阻型糖尿病肾病(DKD)的临床效果。方法选取2020年10月至2022年10月九江市中医医院收治的114例气阴两虚、瘀血内阻型DKD患者作为研究对象,采用随机数字表法分为观察1组、观察2组和对照组,每组各38例。对照组采用单独氯沙坦钾治疗,观察1组采用氯沙坦钾+消渴肾宝丸治疗,观察2组采用氯沙坦钾+消渴肾宝丸+热敏灸治疗,三组患者均连续治疗12周。比较三组患者临床疗效、中医证候积分、血糖及肾功能指标、不良反应。结果三组患者临床疗效比较,差异有统计学意义(P<0.05);观察2组临床疗效高于对照组,差异有统计学意义(P<0.017);对照组与观察1组、观察1组与观察2组临床疗效比较,差异无统计学意义(P>0.05)。三组患者治疗后主症与次症中医证候积分均低于本组治疗前,差异有统计学意义(P<0.05);观察2组主症与次症积分均低于观察1组、对照组,观察1组主症与次症积分低于对照组,差异有统计学意义(P<0.05)。三组患者治疗后血糖及肾功能各指标水平均低于本组治疗前,差异有统计学意义(P<0.05);观察2组治疗后血糖及肾功能各指标水平均低于观察1组、对照组,观察1组血糖及肾功能各指标水平均低于对照组,差异有统计学意义(P<0.05)。三组患者治疗期间均未产生明显的不良反应。结论气阴两虚、瘀血内阻型DKD患者采用消渴肾宝丸联合热敏灸及氯沙坦钾治疗可获得较好的临床效果,各临床症状均得到有效缓解,血糖及肾功能均得到有效控制,无明显不良反应,安全可靠,值得推广。
Objective To investigate the clinical effect of Xiaoke Shenbao Pills combined with heat-sensitive moxibustion in the treatment of Qi-yin deficiency and blood stasis type diabetes kidney disease(DKD).Methods A total of 114 patients with Qi-yin deficiency and blood stasis type DKD treated in Jiujiang Traditional Chinese Medicine Hospital from October 2020 to October 2022 were selected as the research objects,and they were divided into observation group 1,observation group 2 and control group according to random number table method,with 38 cases in each group.Control group was treated with Losartan Potassium alone,observation group 1 was treated with Losartan Potassium+Xiaoke Shenbao Pills,observation group 2 was treated with Losartan Potassium+Xiaoke Shenbao Pills+heat-sensitive moxibustion,all three groups were treated continuously for 12 weeks.The clinical efficacy,traditional Chinese medicine syndrome score,blood glucose and renal function indexes,adverse reactions of the three groups were compared.Results There was significant difference in clinical efficacy among the three groups(P<0.05).The clinical efficacy of observation group 2 was higher than that of control group,and the difference was statistically significant(P<0.017).There was no significant difference in clinical efficacy between control group and observation group 1,observation group 1 and observation group 2(P>0.05).The traditional Chinese medicine syndrome scores of the main and secondary symptoms in the three groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The scores of main disease and secondary disease in observation group 2 were lower than those in observation group 1 and control group,and the scores of main disease and secondary disease in observation group 1 were lower than those in control group,the differences were statistically significant(P<0.05).The levels of blood glucose and renal function indexes in the three groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the levels of blood glucose and renal function indexes in observation group 2 were lower than those in observation group 1 and control group,and the levels of blood glucose and renal function indexes in observation group 1 were lower than those in control group,with statistical significances(P<0.05).There were no obvious adverse reactions in the three groups during treatment.Conclusion Xiaoke Shenbao Pills combined with heat-sensitive moxibustion and Losartan Potassium in the treatment of DKD patients with Qi-yin deficiency and blood stasis can obtain better clinical effects,all clinical symptoms can be effectively alleviated,blood glucose and renal function can be effectively controlled,no obvious adverse reactions occurred,safe and reliable,worthy of promotion.
作者
虞成毕
周文娣
邱悦
YU Chengbi;ZHOU Wendi;QIU Yue(Department of Diabetes,Jiujiang Traditional Chinese Medicine Hospital,Jiangxi Province,Jiujiang332000,China)
出处
《中国当代医药》
CAS
2024年第6期90-94,共5页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202211974)。
关键词
糖尿病肾病
消渴肾宝丸
热敏灸
氯沙坦钾
气阴两虚型
瘀血内阻型
中医证候积分
Diabetes kidney disease
Xiaoke Shenbao Pills
Heat-sensitive moxibustion
Losartan Potassium
Qi-yin deficiency
Blood stasis
Traditional Chinese medicine syndrome score
