摘要
目的探讨基于CiteSpace的肠道菌群与阿尔茨海默病相关性的可视化分析。方法检索2000年1月至2023年3月中国知网和Web of Science核心合集数据库中以“肠道菌群”和“阿尔茨海默病”为主题词的文献,运用CiteSpace 6.1.R6软件对机构、作者、关键词进行分析。结果本研究共纳入文献918篇。中、英文文献发文量均呈上升趋势。中文文献中,北京协和医学院是发文量最多的机构,刘奇是发文量最多的作者;英文文献中,University of California System是发文量最多的机构,Lukiw Walter J是发文量最多的作者。除主题词外“神经炎症”在中文文献出现频次最高;“gut-brain axis”在英文文献出现频次最高。关键词共形成6个中文聚类和15个英文聚类,主要围绕肠道菌群及其代谢物的作用机制展开研究。关键词突现分析共探索出12个中文突现词和15个英文突现词。结论肠道菌群调控阿尔茨海默病病理产物和神经炎症是当前的研究热点;未来的研究方向可能是通过调节肠道菌群干预免疫炎症防治阿尔茨海默病。
Objective To explore visual analysis of the relationship of gut microbiota and Alzheimer’disease based on CiteSpace.Methods The related literatures with the key words“gut microbiota”and“Alzheimer’s disease”in CNKI and web of science core collection database from January 2000 to March 2023 were searched,and the institutions,authors,and keywords were analyzed by CiteSpace 6.1.R6 software.Results A total of 918 articles were included in this study.The number of Chinese and English literatures were on the rise.In Chinese literature,Peking Union Medical College was the institution with the most articles,and Liu Qi published the most articles;in English literature,University of California System was the institution with the most articles,and Lukiw Walter J published the most articles.Except for the subject words,“neuroinflammation”appeared most frequently in Chinese keyword,and“gut-brain axis”appeared most frequently in English literature.Keywords were formed 6 Chinese clustering and 15 English clustering,mainly revolves around the mechanism of action of gut microbiota and its metabolites.Keyword emergence analysis identified 12 Chinese emergent words and 15 English emergent words.Conclusion The regulation of gut microbiota on pathological products and neuroinflammation in Alzheimer’s disease is a current research hotspot.The future research direction may be to intervene in immune inflammation by regulating gut microbiota to prevent and treat Alzheimer’s disease.
作者
廖乃彬
何瑷芯
陈炜
朱小敏
卓桂锋
廖世锋
苏明阳
李倩倩
LIAO Naibin;HE Aixin;CHEN Wei;ZHU Xiaomin;ZHUO Guifeng;LIAO Shifeng;SU Mingyang;LI Qianqian(Graduate School,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530001,China;Encephalopathy,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530023,China)
出处
《中国医药导报》
CAS
2024年第1期81-86,共6页
China Medical Herald
基金
国家自然科学基金地区科学基金项目(82060844)
广西自然科学基金面上项目(2022GXNSFAA035461)
广西中医脑病临床医学研究中心(桂科AD20238028)
广西中医药大学研究生教育创新计划项目(YCSY2023031)。
